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Fertility Preservation in Patients with Severe Ovarian Dysfunction

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Published on: March 25, 2021

Thyroid function in infertile patients undergoing assisted reproduction.

Angela Fumarola¹, Giorgio Grani, Daniela Romanzi

¹Department of Experimental Medicine, Chair of Endocrinology, Sapienza University of Rome, Rome, Italy.

American Journal of Reproductive Immunology (New York, N.Y. : 1989)

|March 26, 2013

Summary

This summary is machine-generated.

Thyroid dysfunction impacts fertility outcomes. Women with normal TSH levels (≤ 2.5 mUI/L) had higher pregnancy rates in assisted reproduction technologies (ART). Autoimmunity also affected pregnancy success.

Keywords:

Embryos ICSI oocytes thyroid thyrotropin

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Published on: October 24, 2025

Area of Science:

Reproductive Endocrinology
Infertility Research
Thyroidology

Background:

Thyroid disease is a common endocrine condition in women of reproductive age.
The relationship between thyroid function and assisted reproduction outcomes is not fully understood.
Thyroid autoimmunity may also play a role in reproductive health.

Purpose of the Study:

To investigate the association between thyroid function (TSH levels) and autoimmunity with outcomes of assisted reproduction technologies (ART).
To evaluate the impact of thyroid status on ovarian stimulation, oocyte and embryo quality, and clinical pregnancy rates.

Main Methods:

Retrospective analysis of 164 women undergoing ART at a university fertility center.
Serum TSH levels, oocyte and embryo parameters, and clinical pregnancy rates were recorded.
Comparison of outcomes based on TSH levels (≤ 2.5 mUI/L vs. > 2.5 mUI/L) and presence of anti-thyroperoxidase antibodies.

Main Results:

A statistically significant higher clinical pregnancy rate was observed in women with TSH ≤ 2.5 mUI/L (22.3%) compared to those with TSH > 2.5 mUI/L (8.9%; P = 0.045).
No pregnancies occurred in women with anti-thyroperoxidase autoantibodies.
Pregnancy occurred in 23.9% of cycles without thyroid autoimmunity (P = 0.02).

Conclusions:

Thyroid function, specifically TSH levels, appears to be associated with clinical pregnancy rates in ART.
Thyroid autoimmunity may negatively impact pregnancy success in women undergoing fertility treatments.
Further research is warranted to elucidate the complex relationship between thyroid dysfunction, autoimmunity, and infertility.