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Related Experiment Video

Updated: May 13, 2026

Isolation of Human Lymphatic Endothelial Cells by Multi-parameter Fluorescence-activated Cell Sorting
07:36

Isolation of Human Lymphatic Endothelial Cells by Multi-parameter Fluorescence-activated Cell Sorting

Published on: May 1, 2015

Acral hemosideric lymphatic malformation.

Lei Wang1, Tianwen Gao, Gang Wang

  • 1Department of Dermatology, Xijing Hospital, Fourth Military Medical University, Xian, China.

Journal of Cutaneous Pathology
|March 26, 2013
PubMed
Summary
This summary is machine-generated.

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This study identifies a unique lymphatic malformation presenting as acral papules or nodules. The proposed name, acral hemosideric lymphatic malformation, reflects its distinct clinical and histopathological features.

Area of Science:

  • Dermatology
  • Vascular Malformations
  • Histopathology

Background:

  • Cutaneous lymphatic malformations are diverse diseases stemming from lymphatic system developmental defects.
  • Understanding these malformations is crucial for accurate diagnosis and treatment.

Purpose of the Study:

  • To characterize a specific, distinctive type of lymphatic malformation.
  • To detail its clinical, histopathological, and immunohistochemical profile.

Main Methods:

  • Analysis of twelve patients with similar clinical and histopathological features.
  • Immunohistochemical staining for CD31, D2-40, Prox1, and Wilms tumor 1 (WT-1).

Main Results:

  • Lesions presented as congenital or early-onset (first 2 years) red to brown papules/nodules on acral sites.

Related Experiment Videos

Last Updated: May 13, 2026

Isolation of Human Lymphatic Endothelial Cells by Multi-parameter Fluorescence-activated Cell Sorting
07:36

Isolation of Human Lymphatic Endothelial Cells by Multi-parameter Fluorescence-activated Cell Sorting

Published on: May 1, 2015

  • Histopathology revealed dermal proliferation of lymphatic vessels with hemosiderin and extravascular red blood cells.
  • Vessels expressed CD31, D2-40, and Prox1, but not WT-1.

    • Conclusions:

    • The findings suggest a unique lymphatic malformation distinct from previously described vascular proliferations.
    • The proposed name 'acral hemosideric lymphatic malformation' accurately reflects the entity's characteristics.
    • This classification aids in differentiating it from other vascular lesions.