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Updated: May 13, 2026

Characterization of pH-Dependent Reversible Self-Assembly of Amyloid Beta 1-40-Coated Gold Colloids
Published on: March 21, 2025
Evidence for age-dependent in vivo conformational rearrangement within Aβ amyloid deposits
Sofie Nyström1, Katarzyna M Psonka-Antonczyk, Pål Gunnar Ellingsen
1IFM-Department of Chemistry, Linköping University , Linköping, Sweden.
Abstract:
Deposition of aggregated Aβ peptide in the brain is one of the major hallmarks of Alzheimer's disease. Using a combination of two structurally different, but related, hypersensitive fluorescent amyloid markers, LCOs, reporting on separate ultrastructural elements, we show that conformational rearrangement occurs within Aβ plaques of transgenic mouse models as the animals age. This important mechanistic insight should aid the design and evaluation of experiments currently using plaque load as readout.
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