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Dopaminergic reward signals selectively decrease fMRI activity in primate visual cortex.

John T Arsenault¹, Koen Nelissen, Bechir Jarraya

¹Laboratory of Neuro and Psychophysiology, KU Leuven Medical School, Campus Gasthuisberg, 3000 Leuven, Belgium.

|March 26, 2013

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Reward signals without visual cues can reduce brain activity in specific visual cortex areas, enhancing learning and memory. This suggests dopamine plays a key role in selective neural plasticity.

Area of Science:

Neuroscience
Cognitive Science
Visual Processing

Background:

Stimulus-reward associations, even without attention, drive perceptual learning, indicating reward-induced plasticity in the visual cortex.
Dopamine release surrounding stimulus-reward pairings selectively strengthens memory, suggesting modulation of neural representations.

Purpose of the Study:

To investigate whether dopaminergic signals can selectively modulate activity within the primate visual cortex.
To explore the role of reward prediction error in mediating these selective modulations.

Main Methods:

Functional magnetic resonance imaging (fMRI) was used to measure visual cortex activity in monkeys.
Experiments involved reward-only trials and intermixed cue-reward trials.
Manipulations included reward magnitude, cue-reward probability, familiarity, and dopamine signaling to assess prediction error.

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Related Experiment Videos

Last Updated: May 13, 2026

Simultaneous Detection of c-Fos Activation from Mesolimbic and Mesocortical Dopamine Reward Sites Following Naive Sugar and Fat Ingestion in Rats

Simultaneous Detection of c-Fos Activation from Mesolimbic and Mesocortical Dopamine Reward Sites Following Naive Sugar and Fat Ingestion in Rats

Published on: August 24, 2016

Studying Food Reward and Motivation in Humans

Studying Food Reward and Motivation in Humans

Published on: March 19, 2014

Investigating Object Representations in the Macaque Dorsal Visual Stream Using Single-unit Recordings

Investigating Object Representations in the Macaque Dorsal Visual Stream Using Single-unit Recordings

Published on: August 1, 2018

Main Results:

Reward presented without a visual cue selectively decreased fMRI activity in previously learned cue representations.
These uncued reward trials strengthened the association between cues and rewards.
Spatially-specific activity modulations were dependent on reward prediction error.

Conclusions:

A cue-selective negative reward signal mechanism gates sensory cortical plasticity.
Dopamine-mediated prediction error signals can selectively downregulate visual cortical activity, facilitating learning.