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Updated: May 13, 2026

Comparative Proteomic Analysis of Whole Kidney, Medulla, and Cortical Tubules in Diabetic Pathogenesis of Kidney Injury in Mice
Published on: May 2, 2025
Diabetes and the kidney in human and veterinary medicine
Carly Anne Bloom1, Jacquie S Rand
1Small Animal Internal Medicine, Small Animal Clinic & Veterinary Teaching Hospital, School of Veterinary Science, The University of Queensland, St Lucia, Queensland 4072, Australia. c.bloom@uq.edu.au
Abstract:
Diabetic nephropathy is a well-recognized clinical consequence of both type 1 and type 2 diabetes mellitus in humans. Major risk factors include poor glycemic control, hypertension, and microalbuminuria, as well as genetic factors. In both type 1 and 2 diabetics with nephropathy, structural changes occur in the kidneys before overt clinical disease. Studies suggest that some of the risk factors and structural renal changes of human diabetes also exist in diabetic dogs and cats. This article assembles existing information on the presence of risk factors, laboratory and histologic findings, and consequences of human diabetic nephropathy as applied to cats.
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