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Updated: May 13, 2026
A Syngeneic Mouse Model of Metastatic Renal Cell Carcinoma for Quantitative and Longitudinal Assessment of Preclinical Therapies
Published on: April 12, 2017
[Renal metastasis of classic seminoma]
Edmundo Erbey Castelán-Maldonado1, César Iván Peña-Ruelas, César Valentín Ignacio-Morales
1Departamento de Anatomía Patológica, Hospital de Especialidades No. 25. Centro Médico Nacional del Noreste. Instituto Mexicano del Seguro Social, Monterrey, México. a.patologica_imss_mty@yahoo.com
Introduction:
Seminoma comprises approximately 50% of testicular germ cell tumors. Renal metastases are infrequent, and are usually recognized at necropsy.
Clinical Case:
A 24 years-old man with history of left radical orchiectomy due to classical seminoma (stage I), and adjuvant radiotherapy, showed elevated levels of beta-human chorionic gonadotropin and lactate dehydrogenase in the eleven month follow-up. Computed tomography showed a 9 × 8 cm lobulated, heterogeneous tumor in the left kidney. The histopathological and immunohistochemical assay demonstrated a classical metastatic seminoma.
Conclusion:
The majority of renal tumors represent primary neoplasm; in patients with extra-renal tumors we must consider the possibility of a metastatic disease.
