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Implementation of Non-invasive Point of Care Transient Elastography for Evaluation of Liver Disease in Pediatric Populations with Cystic Fibrosis
Published on: August 29, 2025
Diabetes in cystic fibrosis
1Chelsea and Westminster Hospital, London SW10 9NH.
Paediatric Respiratory Reviews
|March 26, 2013
Summary
Cystic fibrosis related diabetes (CFRD) is a common complication impacting lung function and survival in cystic fibrosis patients. Insulin therapy improves clinical outcomes, but optimal treatment strategies require further clarification.
Area of Science:
- Endocrinology
- Pulmonology
- Metabolic disorders
Background:
- Cystic fibrosis related diabetes (CFRD) is a prevalent complication in cystic fibrosis (CF).
- It stems from age-related decline in insulin secretion, particularly in individuals with pancreatic insufficiency.
- CFRD is linked to poorer clinical status and increased mortality in CF patients.
Purpose of the Study:
- To review the current understanding of CFRD in cystic fibrosis.
- To discuss the benefits of insulin treatment for CFRD.
- To highlight the ongoing uncertainties regarding treatment selection and glycemic targets.
Main Methods:
- Literature review of studies on CFRD and insulin therapy in cystic fibrosis.
- Analysis of clinical outcomes associated with CFRD and its management.
- Synthesis of current clinical experience and guidelines.
Main Results:
- Insulin treatment for CFRD demonstrates sustained improvements in lung function and nutritional status.
- Despite clinical experience, clear guidelines for initiating insulin therapy are lacking.
- Optimal glycemic targets for CFRD management remain undefined.
Conclusions:
- Insulin therapy is effective in improving key clinical parameters in CFRD patients.
- Further research and consensus are needed to define optimal patient selection and glycemic control strategies for CFRD.
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