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Updated: May 13, 2026

Using a 1064-nm Picosecond Neodymium-Doped Yttrium Aluminum Garnet Laser for Periorbital Hyperpigmentation
Published on: May 23, 2025
Topical treatment of hyperpigmentation disorders
1The Rendon Center for Dermatology and Aesthetic Medicine, Boca Raton, Florida, USA University of Miami, Florida, USA. martarendon@yahoo.com
Abstract:
Hyperpigmentation has traditionally been a relatively difficult condition to treat, especially in darker racial ethnic groups. Multiple topical agents available act upon different steps of the pigmentation pathway. We review these topical agents, their mechanisms of action, and their effectiveness as monotherapy and in combination with other compounds. Ultimately, combination therapy is the most efficacious when considering overall depigmentation as well as treatment time required to achieve clinical improvement.
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