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The Lombardy Rare Donor Programme.

Nicoletta Revelli1, Maria Antonietta Villa1, Cinzia Paccapelo1

  • 1Immunohaematology Reference Laboratory, Immunohaematology and Transfusion Centre, Milan, Italy.

Blood Transfusion = Trasfusione Del Sangue
|March 26, 2013
PubMed
Summary
This summary is machine-generated.

The Lombardy Rare Donor Programme established a registry and bank of rare red blood cell units, enhancing transfusion safety for patients with rare blood types or IgA deficiency.

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Area of Science:

  • Hematology
  • Immunology
  • Public Health

Background:

  • Established in 2005, the Lombardy Rare Donor Programme (LORD-P) is a regional network in Italy comprising 15 blood transfusion departments.
  • Funded with 14.1 million euros from 2005 to 2012, LORD-P aimed to address the needs of a diverse population of approximately 9.8 million, including 250,000 blood donors.

Purpose of the Study:

  • To develop a registry and bank of red blood cell units for individuals with rare blood group phenotypes or IgA deficiency.
  • To provide a 24/7 consultation, testing, and distribution service for rare blood units to meet transfusion needs.

Main Methods:

  • Extensive serological and molecular red blood cell typing was performed on 59,738 donors aged 18-55.
  • Donors were selected based on specific Rh phenotypes (CCDee, ccdee, ccDEE, ccDee) or K-/k- status, with a history of at least two donations.
  • A parallel service was implemented for managing complex red blood cell alloimmunisation and IgA deficiency cases.

Main Results:

  • Identified 8,747 donors rare for common antigen combinations, 538 negative for high-frequency antigens, and 33 with rare Rh phenotypes.
  • By June 2012, the program had a frozen inventory of 1,157 rare red blood cell units.
  • Distributed 8,008 rare red blood cell units to 2,365 patients, with no reported adverse effects, and provided 281 consultations for alloimmunisation cases.

Conclusions:

  • The Lombardy Rare Donor Programme successfully created a valuable resource of rare red blood cell units.
  • The program significantly improved blood transfusion safety and efficacy both within and outside the Lombardy region.
  • LORD-P's participation in the ISBT Working Party on Rare Donors highlights its contribution to the global rare donor community.