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Anatomy of Respiratory System I: Upper Respiratory Tract01:29

Anatomy of Respiratory System I: Upper Respiratory Tract

The upper respiratory tract plays a vital role in the respiratory system, comprising several structures that facilitate air intake and prepare air for the lungs. It also serves as the first line of defense against pathogens and particles. This tract includes the nose and nasal cavity, the oral cavity, the paranasal sinuses, and the pharynx, each with specific functions and features.
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Updated: May 13, 2026

Endoscopic Endonasal Trans-sphenoidal Approach: Minimally Invasive Surgery for Pituitary Adenomas
07:43

Endoscopic Endonasal Trans-sphenoidal Approach: Minimally Invasive Surgery for Pituitary Adenomas

Published on: January 17, 2018

Paranasal sinus cancer.

F Jégoux1, A Métreau, G Louvel

  • 1Service d'ORL et chirurgie maxillo-faciale, CHU de Pontchaillou, rue Henri-Le-Guilloux, 35033 Rennes cedex 9, France.

European Annals of Otorhinolaryngology, Head and Neck Diseases
|March 26, 2013
PubMed
Summary
This summary is machine-generated.

Paranasal sinus cancers are rare, aggressive tumors often diagnosed late. Optimal treatment involves surgery and radiotherapy, but prognosis remains poor with significant recurrence rates.

Keywords:
Anterior skull base surgeryEndoscopic sinus surgeryEthmoid adenocarcinomaIMRTMaxillary sinus squamous cell carcinomaParanasal sinus cancerRadiotherapy

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Area of Science:

  • Oncology
  • Otorhinolaryngology
  • Head and Neck Surgery

Background:

  • Paranasal sinus cancers are rare, aggressive tumors.
  • Diagnosis is often delayed to advanced stages.
  • Distinct risk factors include wood dust exposure and premalignant lesions like inverted papillomas.

Purpose of the Study:

  • To outline the diagnostic criteria for paranasal sinus cancers.
  • To detail the recommended staging and multidisciplinary management approach.
  • To review current treatment strategies and patient prognosis.

Main Methods:

  • Clinical presentation and diagnostic suspicion based on unilateral symptoms, bone lysis, or imaging.
  • Histological examination for definitive diagnosis.
  • Comprehensive staging using CT and MRI of the face, brain, neck, and chest.

Main Results:

  • Two-thirds of tumors are stage T3-T4.
  • Cervical lymph node involvement occurs in 10% of squamous cell carcinomas and 4% of adenocarcinomas.
  • Local recurrence rates are 38%, with a 5-year overall survival of approximately 63%.

Conclusions:

  • Paranasal sinus cancers require management in specialized reference centers.
  • A multidisciplinary approach integrating local, regional, and national expertise is crucial.
  • Optimal treatment combines surgical resection with clear margins and adjuvant intensity-modulated radiotherapy (IMRT).