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Updated: May 13, 2026

In Vivo Inhibition of MicroRNA to Decrease Tumor Growth in Mice
07:02

In Vivo Inhibition of MicroRNA to Decrease Tumor Growth in Mice

Published on: August 23, 2019

MYC-y mice: from tumour initiation to therapeutic targeting of endogenous MYC

Jennifer P Morton1, Owen J Sansom

  • 1Beatson Institute for Cancer Research, Garscube Estate, Switchback Rd, Glasgow G61 1BD, UK.

Molecular Oncology
|March 26, 2013
PubMed

Insights

Genetically engineered mouse models (GEMM) are crucial for studying the oncogene MYC in cancer. These models help understand MYC

Area of Science:

  • Oncology
  • Genetics
  • Molecular Biology

Background:

  • MYC is a well-established oncogene implicated in various malignancies.
  • Genetically engineered mouse models (GEMM) have been instrumental in cancer research.
  • Advancements in mouse models allow for regulated expression of MYC in vivo.

Purpose of the Study:

  • To review the utility of GEMM in investigating MYC's role in tumorigenesis.
  • To explore how MYC levels influence tumor initiation and progression.
  • To summarize current strategies targeting endogenous MYC.

Main Methods:

  • Utilizing transgenic and conditional systems in mice to control MYC expression.
  • Analyzing the impact of MYC in specific tissues and cell lineages.
  • Reviewing existing literature on MYC-driven tumor development.

Main Results:

  • GEMM have elucidated MYC's critical role in tumor initiation and maintenance.
  • Subtle alterations in MYC levels significantly impact tumorigenesis.
  • These models facilitate the study of MYC's oncogenic functions.

Conclusions:

  • GEMM are invaluable for dissecting MYC's function in cancer.
  • Understanding MYC regulation is key to developing targeted therapies.
  • Ongoing research focuses on genetically targeting and therapeutically intervening with MYC.

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