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A Modified Model Preparation for Middle Cerebral Artery Occlusion Reperfusion
Published on: May 31, 2024
Mechanical recanalization with flow restoration in acute ischemic stroke: the ReFlow (mechanical recanalization with
Christian Roth1, Wolfgang Reith, Silke Walter
1Clinic for Diagnostic and Interventional Neuroradiology, Saarland University Hospital, Homburg, Germany.
Objectives:
This study sought to assess the feasibility and safety of a recently described technique of mechanical recanalization with the help of a stent-like device.
Background:
In the special group of acute stroke patients with an intracranial large vessel occlusion, intravenous tissue-type plasminogen activator on its own leads to a good clinical outcome (mRS ≤ 2) in only 15% to 25% of cases. The aforementioned technique of mechanical recanalization showed very promising clinical results.
Methods:
Forty patients presenting within 6 h from stroke symptom onset were enrolled. Mechanical recanalization was performed using a Solitaire FR revascularization device. The primary endpoint of the study was the clinical outcome rated with the help of the modified Rankin Scale (mRS) after 90 days.
Results:
Twenty-four patients (60%) showed a good clinical outcome (mRS ≤ 2) at 90 days. One symptomatic hemorrhage was detected on follow-up computed tomography. The death rate was 12.5% (5 patients). Successful recanalization (Thrombolysis In Cerebral Infarction score ≥ 2b) of the target vessel was achieved in 95% of the patients with a mean of 1.8 runs with the device.
Conclusions:
The ReFlow (Mechanical Recanalization With Flow Restoration in Acute Ischemic Stroke) study shows that mechanical recanalization with flow restoration is highly effective in stroke patients with a large intracranial vessel occlusion presenting within 4.5 h after symptom onset. (Mechanical Recanalization With Flow Restoration in Acute Ischemic Stroke [ReFlow]; NCT01210729).
