Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Disorders of the Skeletal Muscle01:28

Disorders of the Skeletal Muscle

The clinical conditions affecting the skeletal muscle tissue are broadly categorized as musculoskeletal and neuromuscular disorders.
Musculoskeletal disorders
Musculoskeletal disorders involve injuries and conditions affecting the skeletal muscles and associated connective tissues. These disorders can arise from acute biomechanical stresses or chronic overuse and can occur across different age groups. Common injuries include sprains, fractures, and muscular strains, often resulting from...
The Neuromuscular Junction01:19

The Neuromuscular Junction

The nervous system consists of complex motor neuron circuits, including upper motor neurons originating from the cerebral cortex and lower motor neurons starting in the spinal cord, coordinating both voluntary and involuntary movements. Among these, somatic motor neurons activate skeletal muscles and are classified into alpha, beta, and gamma types. Alpha neurons are vital for voluntary movement coordination, while gamma neurons adjust muscle spindle sensitivity, and the function of beta...
Neuromuscular Junction And Blockade01:29

Neuromuscular Junction And Blockade

The site of chemical communication between a motor neuron and a muscle fiber is called the neuromuscular junction (NMJ). The end of the motor neuron at the NMJ divides into a cluster of synaptic end bulbs. The cytoplasm of these bulbs consists of synaptic vesicles enclosing acetylcholine molecules, the principal neurotransmitter released at the NMJ. The region opposite the synaptic bulb that ends in the muscle fiber is called the motor end plate, which has acetylcholine receptors. Within the...
Chemical Synapses01:26

Chemical Synapses

Chemical synapses are specialized sites between two neurons or between a neuron and a non-neuronal cell like a muscle, glandular or sensory cell.
Because chemical synapses depend on the release of neurotransmitter molecules from synaptic vesicles to pass on their signal, there is an approximately one millisecond delay between when the axon potential reaches the presynaptic terminal and when the neurotransmitter leads to opening of postsynaptic ion channels. Additionally, this signaling is...
Chemical Synapses01:26

Chemical Synapses

Chemical synapses are specialized sites between two neurons or between a neuron and a non-neuronal cell like a muscle, glandular or sensory cell.
Because chemical synapses depend on the release of neurotransmitter molecules from synaptic vesicles to pass on their signal, there is an approximately one millisecond delay between when the axon potential reaches the presynaptic terminal and when the neurotransmitter leads to opening of postsynaptic ion channels. Additionally, this signaling is...
Myasthenia Gravis ll: Pathophysiology01:22

Myasthenia Gravis ll: Pathophysiology

The disease process of myasthenia gravis begins at the neuromuscular junction, where antibodies attack key proteins needed for muscle activation. This immune reaction weakens signal transmission, leading to the characteristic muscle fatigue and weakness that define the condition.Immune-Mediated DamageIn most individuals, antibodies target acetylcholine receptors (AChRs) on the postsynaptic membrane of muscle cells. By blocking acetylcholine binding, these antibodies prevent the nerve signal...

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Effects of Strong Inhibition of Cytochrome P450 3A and UDP glucuronosyltransferase 1A9 and Strong Induction of Cytochrome P450 3A on the Pharmacokinetics, Safety, and Tolerability of Soticlestat: Two Drug-Drug Interaction Studies in Healthy Volunteers.

Drug metabolism and disposition: the biological fate of chemicals·2023
Same author

Plasma neurofilament light levels show elevation two years prior to diagnosis of amyotrophic lateral sclerosis in the UK Biobank.

Amyotrophic lateral sclerosis & frontotemporal degeneration·2023
Same author

Electrical impedance myography detects dystrophin-related muscle changes in mdx mice.

Skeletal muscle·2023
Same author

Investigation of the absolute bioavailability, mass balance, metabolism, and excretion of the cholesterol 24-hydroxylase inhibitor soticlestat in healthy volunteers.

British journal of clinical pharmacology·2023
Same author

Efficacy and Safety of Ravulizumab, a Complement C5 Inhibitor, in Adults With Amyotrophic Lateral Sclerosis: A Randomized Clinical Trial.

JAMA neurology·2023
Same author

Qualitative measures that assess functional disability and quality of life in ALS.

Health and quality of life outcomes·2022
Same journal

Physical therapists' experiences treating patients with hip joint-related pain: Facilitators and barriers to rehabilitation.

PM & R : the journal of injury, function, and rehabilitation·2026
Same journal

Adherence to and perceptions of a Peruvian osteoarthritis clinical practice guideline among physiatrists and residents.

PM & R : the journal of injury, function, and rehabilitation·2026
Same journal

Immediate changes in thoracic spine mobility after repetitive pitching in high school baseball players: A randomized controlled trial.

PM & R : the journal of injury, function, and rehabilitation·2026
Same journal

Longitudinal improvements in comfort, mobility, and quality of life with adjustable-volume prosthetic sockets.

PM & R : the journal of injury, function, and rehabilitation·2026
Same journal

Physical activity and exercise participation-Impact on motor and non-motor outcomes in early-stage Parkinson disease: A cross-sectional study.

PM & R : the journal of injury, function, and rehabilitation·2026
Same journal

Innovative technologies for gait rehabilitation in incomplete spinal cord injury: A systematic review and meta-analysis.

PM & R : the journal of injury, function, and rehabilitation·2026
See all related articles

Related Experiment Video

Updated: May 13, 2026

Characterization of Neuromuscular Junctions in Mice by Combined Confocal and Super-Resolution Microscopy
11:03

Characterization of Neuromuscular Junctions in Mice by Combined Confocal and Super-Resolution Microscopy

Published on: December 8, 2021

Neuromuscular junction disorders.

Chiawen Lucy Liang1, Steve Han

  • 1CNS Multispecialty Clinic, 65 Walnut Street, Suite 150, Wellesley, MA 02481, USA. lucypmr@gmail.com

PM & R : the Journal of Injury, Function, and Rehabilitation
|March 26, 2013
PubMed
Summary
This summary is machine-generated.

Myasthenia gravis and Lambert-Eaton myasthenic syndrome are treatable neuromuscular junction disorders. Diagnosis often requires specialized neurophysiological tests like repetitive nerve stimulation and single-fiber electromyography.

More Related Videos

Dissection of Single Skeletal Muscle Fibers for Immunofluorescent and Morphometric Analyses of Whole-Mount Neuromuscular Junctions
08:41

Dissection of Single Skeletal Muscle Fibers for Immunofluorescent and Morphometric Analyses of Whole-Mount Neuromuscular Junctions

Published on: August 14, 2021

Measuring Neuromuscular Junction Functionality
10:40

Measuring Neuromuscular Junction Functionality

Published on: August 6, 2017

Related Experiment Videos

Last Updated: May 13, 2026

Characterization of Neuromuscular Junctions in Mice by Combined Confocal and Super-Resolution Microscopy
11:03

Characterization of Neuromuscular Junctions in Mice by Combined Confocal and Super-Resolution Microscopy

Published on: December 8, 2021

Dissection of Single Skeletal Muscle Fibers for Immunofluorescent and Morphometric Analyses of Whole-Mount Neuromuscular Junctions
08:41

Dissection of Single Skeletal Muscle Fibers for Immunofluorescent and Morphometric Analyses of Whole-Mount Neuromuscular Junctions

Published on: August 14, 2021

Measuring Neuromuscular Junction Functionality
10:40

Measuring Neuromuscular Junction Functionality

Published on: August 6, 2017

Area of Science:

  • Neurology
  • Immunology
  • Neurophysiology

Background:

  • Neuromuscular junction disorders, including myasthenia gravis and Lambert-Eaton myasthenic syndrome, are significant and treatable conditions.
  • These autoimmune disorders attack the neuromuscular junction, impairing neurotransmission and causing fatigable muscle weakness.

Purpose of the Study:

  • To review primary neuromuscular junction disorders.
  • To discuss clinical and laboratory diagnostic approaches.
  • To highlight electrodiagnostic findings from repetitive nerve stimulation and single-fiber electromyography.

Main Methods:

  • Review of primary neuromuscular junction disorders.
  • Discussion of clinical presentation and laboratory workup.
  • Analysis of electrodiagnostic testing, including repetitive nerve stimulation and single-fiber electromyography.

Main Results:

  • Clinical history, examination, and antibody testing are often diagnostic.
  • Specialized neurophysiological tests are crucial for complex or atypical cases.
  • Repetitive nerve stimulation and single-fiber electromyography reveal characteristic patterns in these disorders.

Conclusions:

  • Myasthenia gravis and Lambert-Eaton myasthenic syndrome are distinct, treatable neuromuscular junction diseases.
  • A combination of clinical evaluation and specialized neurophysiological testing ensures accurate diagnosis.
  • Understanding electrodiagnostic findings is key to managing these conditions effectively.