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Related Concept Videos

T Cell Activation and Clonal Selection01:22

T Cell Activation and Clonal Selection

T cells are integral to our adaptive immune system, recognizing and effectively responding to foreign antigens. T cell activation and clonal selection are pivotal in orchestrating this immune response. This article elucidates these mechanisms, detailing the roles of cluster of differentiation (CD) markers, major histocompatibility complex (MHC) molecules, costimulatory signals, and the process of clonal selection.
Naive T cells that have not yet encountered an antigen express two primary CD...
Cytotoxic T Cells-mediated Immune Response01:27

Cytotoxic T Cells-mediated Immune Response

Cytotoxic T cells are a vital component of the immune system. They have the remarkable ability to identify and target antigens on infected or abnormal cells. These antigens often originate from intracellular pathogens such as viruses or abnormal proteins cancer cells produce.
Immunological surveillance is the ability of immune cells to monitor and eliminate infected cells with intracellular pathogens, neoplastically transformed cells, and cells with non-self antigens. Cytotoxic T cells and NK...
T Cell Types and Functions01:24

T Cell Types and Functions

When T cells with CD4 markers are activated, they give rise to two types of effector cells: helper T cells and regulatory T cells. Meanwhile, T cells with CD8 markers differentiate into effector cytotoxic T cells. The differentiation of CD4 T cells into helper T cell subsets, such as Th1, Th2, and Th17 cells, is dependent on the antigen type, antigen-presenting cell, and regulatory cytokines.
Th1 cells stimulate dendritic cells to express necessary co-stimulatory molecules on their surfaces for...
Antigens Involved in Adaptive Immunity01:26

Antigens Involved in Adaptive Immunity

An antigen is any substance the immune system identifies as foreign and potentially harmful to the body, prompting an immune response. Antigens have two functional properties: immunogenicity and reactivity. Immunogenicity is the ability of an antigen to stimulate a specific immune response. At the same time, reactivity describes the antigen's ability to react with the cells and antibodies produced in response to it.
Complete Antigens
Complete antigens possess both immunogenicity and reactivity.

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Related Experiment Video

Updated: May 13, 2026

An Efficient and High Yield Method for Isolation of Mouse Dendritic Cell Subsets
09:09

An Efficient and High Yield Method for Isolation of Mouse Dendritic Cell Subsets

Published on: April 18, 2016

CD56 marks human dendritic cell subsets with cytotoxic potential.

Dessie Roothans1, Evelien Smits, Eva Lion

  • 1Vaccine and Infectious Disease Institute (VAXINFECTIO); Laboratory of Experimental Hematology; University of Antwerp; Antwerp, Belgium.

Oncoimmunology
|March 26, 2013
PubMed
Summary
This summary is machine-generated.

Human dendritic cells (DCs), when stimulated, can express the natural killer (NK)-cell marker CD56. These CD56-positive DCs possess cytotoxic functions beyond their typical roles.

Keywords:
CD56cytotoxicitydendritic cellshumanmyeloid DCsplasmacytoid DCs

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Last Updated: May 13, 2026

An Efficient and High Yield Method for Isolation of Mouse Dendritic Cell Subsets
09:09

An Efficient and High Yield Method for Isolation of Mouse Dendritic Cell Subsets

Published on: April 18, 2016

Characterization of Human Monocyte-derived Dendritic Cells by Imaging Flow Cytometry: A Comparison between Two Monocyte Isolation Protocols
08:31

Characterization of Human Monocyte-derived Dendritic Cells by Imaging Flow Cytometry: A Comparison between Two Monocyte Isolation Protocols

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Generation of Human Monocyte-derived Dendritic Cells from Whole Blood
07:35

Generation of Human Monocyte-derived Dendritic Cells from Whole Blood

Published on: December 24, 2016

Area of Science:

  • Immunology
  • Cell Biology

Background:

  • Dendritic cells (DCs) are key immune regulators.
  • Natural killer (NK) cells are cytotoxic lymphocytes.
  • CD56 is a canonical NK-cell surface marker.

Purpose of the Study:

  • To investigate the expression of CD56 on human dendritic cells.
  • To determine the functional properties of CD56-expressing DCs.

Main Methods:

  • Flow cytometry for surface marker analysis.
  • Functional assays to assess cytotoxic activity.

Main Results:

  • Human plasmacytoid and myeloid DCs can express CD56 upon stimulation.
  • CD56+ DCs exhibit cytotoxic capacity.

Conclusions:

  • Dendritic cells can acquire NK-cell-like properties.
  • CD56 expression signifies an unconventional cytotoxic function in DCs.