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Analysis of Cerebral Vasospasm in a Murine Model of Subarachnoid Hemorrhage with High Frequency Transcranial Duplex Ultrasound
Published on: June 3, 2021
Changes in hemodynamics after placing intracranial stents.
Hiroshi Tanemura1, Fujimaro Ishida, Yoichi Miura
1Department of Neurosurgery, Mie University Graduate School of Medicine, Tsu, Mie, Japan.
Neurologia Medico-Chirurgica
|March 26, 2013
Summary
Intracranial stents in wide-necked cerebral aneurysm treatment may alter blood flow. Computational fluid dynamics analysis showed stents can induce stagnant and disturbed flow, potentially reducing recurrence.
Area of Science:
- Biomedical Engineering
- Medical Imaging
- Fluid Dynamics
Background:
- Stent-assisted coil embolization is effective for wide-necked cerebral aneurysms.
- Reduced angiographic recurrence is linked to this technique.
- Altered hemodynamics from intracranial stents may explain this benefit.
Purpose of the Study:
- To investigate the hemodynamic effects of intracranial stents.
- To utilize computational fluid dynamics (CFD) for analysis.
Main Methods:
- Acquired stent geometry using micro computed tomography.
- Created patient-specific saccular and blister-like aneurysm models.
- Performed transient CFD analysis with and without virtual stent placement.
Main Results:
- Stent placement caused minimal streamline changes in saccular models, slight changes in blister-like models.
- Models with stents showed reduced wall shear stress (WSS) and flow velocity.
- Models with stents exhibited increased oscillatory shear index, WSS gradient, and relative residence time, indicating disturbed flow.
Conclusions:
- Intracranial stent placement can induce stagnant and disturbed blood flow.
- These hemodynamic changes may contribute to reduced aneurysm recurrence after stent-assisted coil embolization.
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