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Updated: May 13, 2026
Optic Nerve Transection: A Model of Adult Neuron Apoptosis in the Central Nervous System
Published on: May 12, 2011
Reversible hypothalamic dysfunction in optic nerve germinoma
Chao-Hsuan Chen1, Hung-Lin Lin, Der-Yang Cho
1Department of Neurosurgery, China Medical University Hospital; and China Medical University, Taichung, Taiwan.
Abstract:
Primary optic apparatus germ cell tumors are rare. There have been only 6 cases reported in the literature. Although they often disturb the hypothalamus-pituitary-adrenal axis and cause progressive visual loss, the influence of treatment outcomes on hypothalamic autoregulation has never been mentioned. Here, we report a patient with an optic nerve germinoma who presented with reversible visual and hypothalamic dysfunction, and we discuss the possible mechanisms and pathogenesis.
