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Targeted Cancer Therapies02:57

Targeted Cancer Therapies

The targeted cancer therapies, also known as “molecular targeted therapies,” take advantage of the molecular and genetic differences between the cancer cells and the normal cells. It needs a thorough understanding of the cancer cells to develop drugs that can target specific molecular aspects that drive the growth, progression, and spread of cancer cells without affecting the growth and survival of other normal cells in the body.
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A Simple Alternative to Stereotactic Injection for Brain Specific Knockdown of miRNA
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A Simple Alternative to Stereotactic Injection for Brain Specific Knockdown of miRNA

Published on: December 26, 2015

miRNA-Based Therapeutic Strategies.

Masaharu Ishida1, Florin M Selaru

  • 1Division of Gastroenterology and Hepatology School of Medicine Johns Hopkins University 720 Rutland Avenue, Ross 950, Baltimore, MD 21205 (410) 614-3811.

Current Anesthesiology Reports
|March 26, 2013
PubMed
Summary

Micro-RNAs (miRNAs) are key regulators in health and disease. This review covers advances in miRNA therapeutics, including strategies to up-regulate or down-regulate miRNAs and overcome challenges like off-target effects.

Keywords:
AntagomirCancerFibrosisHepatocellular carcinomaInhibitorMimicOff-target effectOncomiRNAsPathobiologySBMASpinal and bulbar muscular atrophyTSmiRNAsTherapyTumor suppressor miRNAsmiRNAmicroRNA

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Area of Science:

  • Molecular Biology
  • Genetics
  • Biochemistry

Background:

  • Micro-RNAs (miRNAs) are short non-coding RNAs regulating gene expression.
  • miRNAs are implicated in various physiological processes and diseases.
  • Therapeutic applications of miRNAs are under active investigation.

Purpose of the Study:

  • To review recent advancements in miRNA-based therapeutic strategies.
  • To discuss methods for modulating miRNA levels for therapeutic benefit.
  • To highlight challenges and potential solutions in miRNA therapy development.

Main Methods:

  • Review of current literature on miRNA therapeutics.
  • Discussion of techniques for miRNA up-regulation (synthetic miRNAs, vectors).
  • Analysis of methods for miRNA down-regulation (anti-sense nucleotides).

Main Results:

  • miRNA dysregulation is linked to numerous diseases.
  • Strategies exist to increase or decrease miRNA activity.
  • Chemical modifications enhance stability and specificity of miRNA therapeutics.

Conclusions:

  • miRNA therapeutics offer promising avenues for disease treatment.
  • Overcoming challenges such as off-target effects and toxicity is crucial.
  • Continued research is vital for realizing the full potential of miRNA-based therapies.