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Targeted treatment for advanced soft tissue sarcoma: profile of pazopanib

Rajeev Rajendra1, Robin L Jones, Seth M Pollack

  • 1University of Washington/Fred Hutchinson Cancer Research Center, Seattle, WA, USA.

Oncotargets and Therapy
|March 26, 2013
PubMed

Insights

Pazopanib, an antiangiogenic drug, improved progression-free survival in patients with metastatic soft tissue sarcoma compared to placebo. This highlights pazopanib as a novel therapeutic option for advanced soft tissue sarcomas.

Area of Science:

  • Oncology
  • Pharmacology

Background:

  • Soft tissue sarcomas are rare adult solid tumors.
  • Current treatments like chemotherapy offer limited survival benefits for metastatic disease.

Purpose of the Study:

  • To review the rationale and clinical evidence for pazopanib in treating soft tissue sarcomas.
  • To evaluate pazopanib as a novel therapeutic agent for advanced soft tissue sarcomas.

Main Methods:

  • Review of laboratory and clinical data.
  • Discussion of the Phase III PALETTE study (pazopanib for metastatic soft-tissue sarcoma).

Main Results:

  • Pazopanib demonstrated improved progression-free survival in patients with metastatic soft tissue sarcoma.
  • The study was a randomized, double-blind, placebo-controlled Phase III trial.

Conclusions:

  • Antiangiogenic agents, like pazopanib, show promise in treating soft tissue sarcomas.
  • Pazopanib is a viable treatment option for patients with metastatic or inoperable soft tissue sarcomas.
Keywords:
metastaticpazopanibsarcoma

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