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Updated: May 13, 2026

A Robust Discovery Platform for the Identification of Novel Mediators of Melanoma Metastasis
Published on: March 8, 2022
Forging a link between oncogenic signaling and immunosuppression in melanoma
Jahan S Khalili1, Patrick Hwu, Gregory Lizée
1Department of Melanoma Medical Oncology; The Center for Cancer Immunology Research; The University of Texas MD Anderson Cancer Center; Houston, TX USA.
Abstract:
Immunosuppressive tumor microenvironments limit the efficacy of T cell-based immunotherapy. We have recently demonstrated that the inhibition of BRAFV600E with vemurafenib relieves interleukin-1 (IL-1)-induced T-cell suppression as mediated by melanoma tumor associated fibroblasts (TAFs). These results suggest that inhibitors of the MAPK pathway in combination with T cell-based immunotherapies may induce long-lasting and durable responses.
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