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Updated: May 13, 2026

Catheter Ablation in Combination With Left Atrial Appendage Closure for Atrial Fibrillation
Published on: February 26, 2013
What is essential for the elimination of persistent or chronic atrial fibrillation?
1Department of Cardiovascular Surgery, Graduate School of Medicine, Hiroshima University, Hiroshima, Japan, sueda@hiroshima-u.ac.jp.
Insights
The pulmonary vein box isolation effectively treats chronic atrial fibrillation (AF). Complete isolation of pulmonary veins is crucial for eliminating AF, building on earlier research into AF triggers and treatments.
Area of Science:
- Cardiac Electrophysiology
- Interventional Cardiology
- Atrial Fibrillation Pathophysiology
Background:
- Lone atrial fibrillation (AF) was historically treated with the maze procedure, based on the multiple reentry theory.
- Ectopic foci originating from pulmonary veins were identified as triggers for paroxysmal AF.
- Chronic AF involves complex electrophysiological substrates distributed around the pulmonary veins.
Purpose of the Study:
- To demonstrate the efficacy of the pulmonary vein box isolation procedure for chronic atrial fibrillation (AF).
- To emphasize the critical role of complete pulmonary vein isolation in AF elimination.
Main Methods:
- Pulmonary vein box isolation procedure.
- Utilizing insights from the maze procedure and ectopic foci discovery.
- Application of complex fractionated atrial electrogram (CFAE) principles for substrate modification.
Main Results:
- The pulmonary vein box isolation procedure proved effective in managing chronic AF.
- Complete isolation of all pulmonary veins was demonstrated as essential for AF elimination.
Conclusions:
- Pulmonary vein box isolation is a viable and effective strategy for chronic AF.
- Complete isolation of pulmonary veins is a necessary condition for successful AF treatment.
Abstract:
Dr. James Cox devised the maze procedure as a radical intervention for lone atrial fibrillation (AF) based on the multiple reentry theory. Dr. Micheal Haissaguerre discovered ectopic foci from the pulmonary veins were the trigger for paroxysmal AF. We demonstrated the efficacy of the pulmonary vein box isolation procedure for chronic AF. Dr. Koonlfawee Nademanee reported the complex fractionated atrial electrogram (CFAE) procedure to eliminate the substrate of chronic AF, which is distributed around the pulmonary veins. The complete isolation of all pulmonary veins is essential for the elimination of AF.
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