Population data for 30 insertion-deletion markers in a Korean population.

Area of Science:

• Forensic Genetics
• Population Genetics
• Human Identification

Background:

• Insertion-deletion polymorphisms (Indels) are valuable genetic markers.
• The Investigator DIPplex® kit offers a set of Indels for forensic analysis.
• Understanding population-specific forensic parameters is crucial for accurate identification.

Purpose of the Study:

• To evaluate the forensic parameters of 30 Indels from the Investigator DIPplex® kit in a Korean population.
• To compare the discriminative power of the DIPplex® kit with existing Short Tandem Repeat (STR) kits.
• To assess the potential of these Indels as ancestry informative markers for Asian populations.

Main Methods:

• Genotyping of 30 Indels using the Investigator DIPplex® kit in 100 Korean individuals.
• Calculation of forensic parameters including match probability and combined power of discrimination.
• Comparative analysis with COfiler® and Profiler Plus® STR kits.
• Comparison with international population data for ancestry marker assessment.

Main Results:

• The combined power of discrimination for the 30 Indels reached 0.99999999995.
• Match probabilities ranged from 0.353 to 0.789.
• The DIPplex® kit demonstrated higher discrimination in Koreans compared to six COfiler® STRs, but lower than nine Profiler Plus® STRs.
• Several Indels showed potential as Asian ancestry informative markers.

Conclusions:

• The Investigator DIPplex® kit provides high forensic discrimination in the Korean population.
• The Indels analyzed offer a valuable tool for human identification and kinship analysis.
• Certain Indels within the DIPplex® kit can be utilized as ancestry informative markers for Asian populations, aiding in forensic investigations.