Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Types of Biopharmaceutical Studies: Controlled and Non-Controlled Approaches01:23

Types of Biopharmaceutical Studies: Controlled and Non-Controlled Approaches

Biopharmaceutical studies constitute a vital field aiming to enhance drug delivery methods and refine therapeutic approaches, drawing upon diverse interdisciplinary knowledge. In research methodologies, the choice between controlled and non-controlled studies significantly influences the study's reliability and accuracy.
Non-controlled studies, commonly employed for initial exploration, lack a control group, rendering them susceptible to biases and external influences. In contrast, controlled...
Bioequivalence Data: Statistical Interpretation01:16

Bioequivalence Data: Statistical Interpretation

The statistical interpretation of bioequivalence data is a significant aspect of pharmaceutical research. Bioequivalence refers to the absence of any significant difference in the rate and extent to which the active ingredient in pharmaceutical products becomes available at the site of drug action when administered at the same molar dose under similar conditions. This helps determine if different drug products have similar absorption rates, ensuring their interchangeability.Statistical...
Bioequivalence: Overview01:16

Bioequivalence: Overview

Pharmaceutical equivalents, by definition, are drug products with the same active ingredient in the same quantities, encapsulated in identical dosage forms, and intended for the same administration routes. These pharmaceutical equivalents are deemed bioequivalent if the bioavailability of the active entity in the drug preparations is similar. Moreover, pharmaceutical equivalents demonstrating bioequivalence are also regarded as therapeutically equivalent. This means that when used as directed,...
Bioequivalence studies: Biowaivers01:13

Bioequivalence studies: Biowaivers

In certain scenarios, in vitro dissolution tests can replace in vivo bioequivalence studies. This is particularly true when a drug product, though available in varying strengths, maintains proportional similarity in its active and inactive ingredients. In such cases, the need for in vivo bioequivalence studies for lower strength variants may be waived, provided dissolution tests and in vivo studies on the highest strength yield satisfactory results.Bioequivalence can be indicated through...
Bioequivalence Experimental Study Designs: Repeated Measures, Cross-Over, Carry-Over, and Latin Square Designs01:15

Bioequivalence Experimental Study Designs: Repeated Measures, Cross-Over, Carry-Over, and Latin Square Designs

Bioequivalence experimental study designs play a pivotal role in testing the effectiveness of various treatments. Key among these are the repeated measures, cross-over, carry-over, and Latin square designs. In the repeated measures design, each subject receives all treatments, allowing for temporal comparisons. This type of design is useful in reducing variability but requires careful planning to avoid bias.The cross-over design, an economical method, involves sequential administration of...

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Real-world patterns of healthcare use, costs, and survival in diffuse large B-cell lymphoma: a nationwide Swedish register study.

The European journal of health economics : HEPAC : health economics in prevention and care·2026
Same author

Early Adulthood Outcomes Among Individuals With Neurologic Impairment and Technology Assistance.

Pediatrics·2026
Same author

Previable Preterm Premature Rupture of the Membranes Reaching Viability: Canadian Outcomes.

Journal of obstetrics and gynaecology Canada : JOGC = Journal d'obstetrique et gynecologie du Canada : JOGC·2026
Same author

An Empirical Comparison of Statistical Methods for Estimating Treatment Effects on EQ-5D in Randomized Clinical Trials.

Value in health : the journal of the International Society for Pharmacoeconomics and Outcomes Research·2026
Same author

Short- and Long-Term Healthcare Costs Attributable to Hepatitis B Among Newcomers to Ontario, Canada: A Matched Cohort Study.

Canadian journal of gastroenterology & hepatology·2026
Same author

Impacts beyond the child: A theoretical framework of pediatric economic evaluation from a family perspective.

Social science & medicine (1982)·2026

Related Experiment Videos

Comparing EQ-5D valuation studies: a systematic review and methodological reporting checklist.

Feng Xie1,2, Kathryn Gaebel2, Kuhan Perampaladas1,2

  • 1Department of Clinical Epidemiology and Biostatistics, McMaster University, Hamilton, ON, Canada (FX, KP, BD, EP).

Medical Decision Making : an International Journal of the Society for Medical Decision Making
|March 26, 2013
PubMed
Summary

Country-specific EQ-5D scoring algorithms are increasingly important. This review highlights study variations, identifies factors influencing health utilities, and introduces a checklist (CREATE) for reporting EQ-5D valuation studies.

Keywords:
EQ-5Dhealth utilityreporting checklistscoring algorithmvaluation

Related Experiment Videos

Area of Science:

  • Health Economics
  • Outcome Research
  • Psychometrics

Background:

  • Growing global interest in country-specific EQ-5D scoring algorithms.
  • EQ-5D (EuroQol five-dimensional questionnaire) is a widely used health outcome measure.
  • Need for standardized reporting of EQ-5D valuation studies.

Purpose of the Study:

  • Systematically review existing EQ-5D valuation studies.
  • Identify strengths and limitations of current methodologies.
  • Explore heterogeneity in observed utilities and propose a reporting checklist.

Main Methods:

  • Systematic literature search of multiple databases (Medline, EMBASE, NHS EED) and proceedings (1991-2012).
  • Independent screening and data extraction by multiple reviewers.
  • Meta-regression to explore heterogeneity in utilities.

Main Results:

  • 31 studies were included, primarily using Time Trade-Off (TTO) or Visual Analogue Scale (VAS) techniques.
  • Significant heterogeneity in study design, sample characteristics, and scoring algorithms observed.
  • Demographic and national factors (e.g., gender, education, healthcare expenditure) associated with utility differences.

Conclusions:

  • Existing EQ-5D valuation studies exhibit considerable variability.
  • A methodological checklist, CREATE (Checklist for Reporting Valuation Studies of the EQ-5D), is proposed.
  • CREATE aims to improve the quality and comparability of future EQ-5D valuation studies.