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Related Experiment Videos

Ionised calcium during haemodialysis.

S Conceicao, N A Hoenich, M K Ward

    Proceedings of the European Dialysis and Transplant Association. European Dialysis and Transplant Association
    |January 1, 1977
    PubMed
    Summary

    Low calcium dialysate (1.5-1.6 mmol/L) effectively raises ionized calcium levels in hemodialysis patients. This approach also helps suppress parathyroid hormone (PTH) levels both before and during dialysis treatment.

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    Area of Science:

    • Nephrology
    • Mineral and Bone Disorder

    Background:

    • High calcium dialysate is popular globally, but UK centers predominantly use lower concentrations (1.5-1.6 mmol/L).
    • The impact of standard UK dialysate calcium levels on ionized calcium and parathyroid hormone (PTH) requires further elucidation.

    Purpose of the Study:

    • To assess the efficacy of a 1.5-1.6 mmol/L dialysate calcium concentration in hemodialysis patients.
    • To evaluate the effect of this dialysate calcium level on ionized calcium and PTH levels.

    Main Methods:

    • A study involving eleven hemodialysis patients.
    • Monitoring of ionized calcium and PTH levels before and during dialysis using a 1.5-1.6 mmol/L calcium dialysate.

    Main Results:

    • Dialysate calcium at 1.5-1.6 mmol/L was sufficient to increase ionized calcium levels.

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  • Patients exhibited minimal pre-dialysis PTH elevation, which was further suppressed during dialysis.

    • Conclusions:

    • Standard UK dialysate calcium concentrations (1.5-1.6 mmol/L) are adequate for achieving target ionized calcium levels.
    • This dialysate calcium level effectively suppresses PTH, indicating its utility in managing secondary hyperparathyroidism in hemodialysis.