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Updated: May 13, 2026

Production and Detection of Reactive Oxygen Species (ROS) in Cancers
Published on: November 21, 2011
The reactivity of α-oxoaldehyde with reactive oxygen species in diabetes complications
Yuriko Matsumura1, Atsuo Iwasawa, Toshihiro Kobayashi
1Department of Bioengineering, Graduate School of Bioscience and Biochemistry, Tokyo Institute of Technology, 4259-G1-25, Nagatsuda-cho, Midori-ku, Yokohama 226-8502, Japan.
Abstract:
The reactions of three α-oxoaldehydes (methylglyoxal, glyoxal, and pyruvic acid) with hydroxyl radicals generated by sonolysis of water were investigated using an electron spin resonance (electron paramagnetic resonance) spin-trapping method, and their reaction kinetics were investigated. It is apparent from our experimental results that methylglyoxal exhibits the highest reactivity of the three α-oxoaldehydes. These α-oxoaldehydes can react with hydroxyl radicals faster than other well-known antioxidants can. The reactivity of hydroxyl radicals is higher than that of hydrogen peroxides.
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