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A Modified Trier Social Stress Test for Vulnerable Mexican American Adolescents

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Does exposure to stressors predict changes in physiological dysregulation?

Dana A Glei¹, Noreen Goldman, Chih-Hsun Wu

¹Center for Population and Health, Georgetown University, Washington, DC, USA. dag77@georgetown.edu

Annals of Behavioral Medicine : a Publication of the Society of Behavioral Medicine

|March 26, 2013

Summary

Stress burden showed weak associations with physiological dysregulation, particularly inflammation, in older Taiwanese men. No significant effects were found in women, suggesting potential sex differences in stress response.

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Area of Science:

Physiological sciences
Gerontology
Epidemiology

Background:

The allostatic load framework posits that chronic stress leads to multi-system physiological dysregulation.
Understanding the long-term impact of stress on health is crucial for public health initiatives.

Purpose of the Study:

To examine how stress burden influences physiological dysregulation over time.
Investigate the relationship between cumulative stressors and changes in biomarkers.

Main Methods:

Population-based cohort study in Taiwan (n=521, aged 54+).
Stressors assessed via life events, chronic strain (1996-2000), and earthquake trauma (1999).
Physiological dysregulation measured using 17 biomarkers (metabolic, inflammatory, neuroendocrine) in 2000 and 2006.

Main Results:

In men, chronic strain was linked to increased dysregulation (β=0.08) and life events to increased inflammation (β=0.10).
These associations were modest and primarily observed in inflammatory markers.
No statistically significant associations were found between stress burden and physiological dysregulation in women.

Conclusions:

Evidence suggests a weak association between stress burden and changes in physiological dysregulation.
Findings indicate potential sex-specific effects of stress on physiological health in older adults.