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Related Experiment Video

Updated: Jan 9, 2026

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Evaluation of Thioperamide Effects Using Rat's Trachea Model.

Feng-Hsiang Chiu1, Hsing-Won Wang

  • 1Department of Otolaryngology-Head and Neck Surgery, Tri-Service General Hospital, National Defense Medical Center, Taipei, Taiwan.

Clinical and Experimental Otorhinolaryngology
|March 26, 2013
PubMed
Summary
This summary is machine-generated.

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Desmopressin nasal spray inhibiting parasympathetic function on isolated tracheal smooth muscle.

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Thioperamide, a histamine H3 receptor antagonist, relaxes rat trachea smooth muscle and inhibits contractions. High concentrations may block parasympathetic function, affecting tracheal response.

Area of Science:

  • Pharmacology
  • Respiratory Physiology

Background:

  • Thioperamide is a histamine H3 receptor antagonist.
  • Tracheal effects are possible following drug administration via inhalation.

Purpose of the Study:

  • To investigate the in vitro effects of thioperamide on rat trachea.
  • To determine thioperamide's impact on tracheal smooth muscle contractility.

Main Methods:

  • Isolated rat trachea was studied in a muscle bath.
  • Tracheal contractility was measured in response to methacholine and electrical field stimulation.
  • Effects on resting tension, methacholine-induced contraction, and electrically-induced contraction were assessed.

Main Results:

  • Thioperamide caused significant relaxation up to 10(-4) M.
Keywords:
AsthmaIn vitroThioperamideTrachea

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  • Electrical field stimulation-induced contractions were inhibited by thioperamide.
  • Basal tracheal tension was minimally affected by increasing thioperamide concentrations.

    • Conclusions:

    • High concentrations of thioperamide may antagonize cholinergic receptors.
    • Parasympathetic function of the trachea can be blocked by thioperamide at high concentrations.