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Efficient Construction of Drug-like Bispirocyclic Scaffolds Via Organocatalytic Cycloadditions of α-Imino γ-Lactones and Alkylidene Pyrazolones
Published on: February 7, 2019
Acantholactone, a new manzamine related alkaloid with an unprecedented δ-lactone and ε-lactam ring system
Amir E Wahba1, Yann Fromentin, Yike Zou
1Department of Pharmacognosy, The School of Pharmacy, The University of Mississippi, University, MS 38677, USA ; Department of Chemistry, Faculty of Science, Damietta University, Egypt.
Abstract:
A new manzamine-related alkaloid with unprecedented δ-lactone and ε-lactam rings called acantholactone (2), was isolated from the Indonesian sponge Acanthostrongylophora sp. The relative configuration of the two new ring systems was established through detailed analysis of NOESY correlations combined with molecular modeling studies. The absolute configuration of 2 was determined as 12S, 24R, 25R, 26R by comparing the computed electronic circular dichroism (ECD) spectra with experimental values.
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