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Related Concept Videos

Regulation of Food Intake01:30

Regulation of Food Intake

Short-term regulation of food intake primarily involves neural signals from the gastrointestinal (GI) tract, blood nutrient levels, and GI tract hormones. Communication between the gut and brain via vagal nerve fibers plays a significant role in evaluating the contents of the gut. Clinical studies have shown that protein ingestion produces a more prolonged response in these nerve fibers compared to an equivalent amount of glucose. Additionally, the activation of stretch receptors caused by GI...
Transducer Mechanism: Enzyme-Linked Receptors01:27

Transducer Mechanism: Enzyme-Linked Receptors

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Cell Specific Gene Expression01:58

Cell Specific Gene Expression

Multicellular organisms contain a variety of structurally and functionally distinct cell types, but the DNA in all the cells originated from the same parent cells. The differences in the cells can be attributed to the differential gene expression. Liver cells, whose functions include detoxification of blood, production of bile to metabolize fats, and synthesis of proteins essential for metabolism, must express a specific set of genes to perform their functions. Gene expression also varies with...
Regulation of Nuclear Protein Sorting01:45

Regulation of Nuclear Protein Sorting

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Hormonal Regulation01:40

Hormonal Regulation

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NF-κB-dependent Signaling Pathway02:26

NF-κB-dependent Signaling Pathway

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NF-κB-dependent Signaling Mechanism
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Related Experiment Video

Updated: May 13, 2026

A RAPID Method for Blood Processing to Increase the Yield of Plasma Peptide Levels in Human Blood
11:36

A RAPID Method for Blood Processing to Increase the Yield of Plasma Peptide Levels in Human Blood

Published on: April 28, 2016

Multi-functional peptide hormone NUCB2/nesfatin-1.

Suleyman Aydin1

  • 1Department of Medical Biochemistry and Clinical Biochemistry (Firat Hormones Research Group), Medical School, Firat University, 23119, Elazig, Turkey, saydin1@hotmail.com.

Endocrine
|March 26, 2013
PubMed
Summary

Nesfatin-1, a hormone derived from the NUCB2 protein, regulates appetite and food intake. This review explores its discovery, effects on various physiological functions, and potential clinical uses.

Area of Science:

  • Endocrinology
  • Neuroscience
  • Molecular Biology

Background:

  • Nesfatin-1 is a recently discovered hormone derived from the NUCB2 protein.
  • It is known to be regulated by hunger and satiety signals.
  • Nesfatin-1 has demonstrated an anorexigenic effect, limiting food intake.

Purpose of the Study:

  • To review the discovery, designation, and biochemical structure of nesfatin-1.
  • To present scientific evidence supporting its role in appetite regulation.
  • To discuss its physiological effects and potential clinical applications.

Main Methods:

  • Literature review of human and animal studies on nesfatin-1.
  • Analysis of biochemical and physiological data.
  • Exploration of existing research on nesfatin-1's functions.

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Peptide-based Identification of Functional Motifs and their Binding Partners
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Peptide-based Identification of Functional Motifs and their Binding Partners

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Important Endpoints and Proliferative Markers to Assess Small Intestinal Injury and Adaptation using a Mouse Model of Chemotherapy-Induced Mucositis
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Important Endpoints and Proliferative Markers to Assess Small Intestinal Injury and Adaptation using a Mouse Model of Chemotherapy-Induced Mucositis

Published on: May 12, 2019

Related Experiment Videos

Last Updated: May 13, 2026

A RAPID Method for Blood Processing to Increase the Yield of Plasma Peptide Levels in Human Blood
11:36

A RAPID Method for Blood Processing to Increase the Yield of Plasma Peptide Levels in Human Blood

Published on: April 28, 2016

Peptide-based Identification of Functional Motifs and their Binding Partners
14:28

Peptide-based Identification of Functional Motifs and their Binding Partners

Published on: June 30, 2013

Important Endpoints and Proliferative Markers to Assess Small Intestinal Injury and Adaptation using a Mouse Model of Chemotherapy-Induced Mucositis
07:05

Important Endpoints and Proliferative Markers to Assess Small Intestinal Injury and Adaptation using a Mouse Model of Chemotherapy-Induced Mucositis

Published on: May 12, 2019

Main Results:

  • Nesfatin-1, a fragment of NUCB2, limits food intake.
  • Evidence supports its involvement in various functions including mood, stress, and reproduction.
  • The roles of nesfatin-2 and nesfatin-3 remain largely unknown.

Conclusions:

  • Nesfatin-1 is a significant hormone with a clear role in appetite control.
  • Further research is needed to elucidate the functions of nesfatin-2 and nesfatin-3.
  • Nesfatin-1 holds promise for potential clinical applications in metabolic and neurological disorders.