Synthesis and application of a chiral ionic liquid functionalized β-cyclodextrin as a chiral selector in capillary
Jia Yu1, Lihua Zuo, Hongjiao Liu
1Shenyang Pharmaceutical University, Shenyang, People's Republic of China.
Abstract:
A novel chiral ionic liquid functionalized β-cyclodextrin, 6-O-2-hydroxpropyltrimethylammonium-β-cyclodextrin tetrafluoroborate ([HPTMA-β-CD][BF4]), was synthesized and used as a chiral selector in capillary electrophoresis. [HPTMA-β-CD][BF4] not only increased the solubility in aqueous buffer in comparison with the parent compound, but also provided a stable reversal electroosmotic flow, and the enantioseparation of eight chiral drugs was examined in phosphate buffer containing [HPTMA-β-CD][BF4] as the chiral selector. The effects of the [HPTMA-β-CD][BF4] concentration and the background electrolyte pH were studied. Moreover, the chiral separation abilities of β-CD and [HPTMA-β-CD][BF4] were compared and possible mechanisms for the chiral recognition of [HPTMA-β-CD][BF4] are discussed.
More Related Videos
09:44Development, Characterization, and Evaluation of CAGE-based Ionic Liquid Systems for Transdermal Delivery
Published on: September 26, 2025
10:14Synthesis and Purification of Iodoaziridines Involving Quantitative Selection of the Optimal Stationary Phase for Chromatography
Published on: May 16, 2014
Related Concept Videos
Capillary Electrophoresis: Applications
Capillary zone electrophoresis (CZE) separates ionic components based on their electrophoretic mobility. It has been used to separate proteins, amino acids,...
Ion-Exchange Chromatography
High-Performance Liquid Chromatography: Introduction
In HPLC, two phases play a critical role in the separation process:
High-Performance Liquid Chromatography: Elution Process
Electrophoresis: Overview
There...
Size-Exclusion Chromatography
Silica particles offer advantages such as rigidity,...
