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Interventional treatment of hypertension: a new paradigm

W Schuyler Jones1, Sreekanth Vemulapalli, Manesh R Patel

  • 1Duke Clinical Research Institute, Duke University Medical Center, Box 3126, Durham, NC, 27710, USA. schuyler.jones@dm.duke.edu

Current Cardiology Reports
|March 26, 2013
PubMed

Insights

Resistant hypertension affects many patients despite lifestyle changes and medication. This review covers interventional treatments targeting the kidney and nervous system to manage uncontrolled blood pressure and reduce cardiovascular risk.

Area of Science:

  • Cardiovascular Medicine
  • Nephrology
  • Neurology

Background:

  • Hypertension is a leading cause of global mortality, contributing to over 7 million deaths annually.
  • Uncontrolled blood pressure (BP) affects up to 50% of patients, increasing risks of myocardial infarction and stroke.
  • Existing treatments like lifestyle changes and pharmacotherapy are insufficient for a significant patient subset.

Purpose of the Study:

  • To review current interventional treatments for resistant hypertension.
  • To explore novel therapeutic targets for managing uncontrolled BP.
  • To summarize findings from existing and emerging studies on interventional therapies.

Main Methods:

  • Review of prior and recent studies on interventional treatments for resistant hypertension.
  • Focus on physiologic targets including renal blood flow, carotid baroreflex, and renal sympathetic nervous system.
  • Analysis of treatment efficacy and patient outcomes.

Main Results:

  • Interventional strategies offer potential for managing resistant hypertension.
  • Targeting renal and neural pathways shows promise in controlling BP.
  • Further research is ongoing to establish the full scope of these treatments.

Conclusions:

  • Resistant hypertension remains a significant clinical challenge despite conventional therapies.
  • Interventional treatments targeting specific physiologic systems represent a promising therapeutic avenue.
  • These approaches may help mitigate cardiovascular morbidity and mortality in high-risk patients.

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