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Updated: May 13, 2026
07:36
Isolation of Human Lymphatic Endothelial Cells by Multi-parameter Fluorescence-activated Cell Sorting
Published on: May 1, 2015
Lymphatic malformations of the orbit.
Susanne Wiegand1, Behfar Eivazi, Linda M Bloch
1Department of Otolaryngology, Head and Neck Surgery, University Hospital Giessen & Marburg, Marburg, Germany.
Clinical and Experimental Otorhinolaryngology
|March 26, 2013
Summary
Orbital lymphatic malformations are rare and challenging to treat. Treatment decisions for these orbital masses depend on size and location, with close monitoring advised for untreated cases.
Area of Science:
- Ophthalmology
- Vascular Malformations
- Orbital Diseases
Background:
- Lymphatic malformations (LMs) of the orbit are uncommon orbital masses, accounting for 1-8% of all cases.
- These lesions are challenging to manage due to their infiltrative nature into surrounding orbital structures.
Purpose of the Study:
- To analyze the clinical courses and evaluate therapeutic options for orbital lymphatic malformations.
Main Methods:
- Retrospective review of 13 patients with orbital lymphatic malformations diagnosed via magnetic resonance imaging (MRI) between 1998 and 2009.
- Analysis of clinical data, including lesion location, treatment strategies, and outcomes.
Main Results:
- Four patients had isolated intraorbital LMs; three underwent complete resection, one was closely monitored.
- Three patients with intraorbital LMs and conjunctival involvement had surgical debulking with good outcomes.
- Six patients presented with intra- and periorbital LMs; three were managed with a watch-and-wait approach, while three received surgical intervention (one with sclerotherapy), resulting in residual malformations.
Conclusions:
- Orbital LM behavior is inconsistent, making standardized treatment recommendations difficult.
- Treatment decisions should be individualized based on LM size and location.
- Patients managed conservatively require monitoring for visual deterioration, indicating potential need for intervention.
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