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Clinical Trials

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Basics of Multivariate Analysis in Neuroimaging Data

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Advanced MR techniques in multicenter clinical trials.

Edward Ashton¹, Jonathan Riek

¹VirtualScopics, Inc., Rochester, New York 14625, USA. ashton@virtualscopics.com

Journal of Magnetic Resonance Imaging : JMRI

|March 26, 2013

Summary

This summary is machine-generated.

Advanced magnetic resonance imaging (MRI) techniques can now be consistently implemented across multiple clinical trial sites. This enables better assessment of targeted therapeutics by measuring changes in tumor microvasculature, overcoming previous limitations.

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Area of Science:

Radiology
Oncology
Clinical Trials

Background:

Magnetic resonance imaging (MRI) has been used in clinical trials for over 20 years, primarily for subjective interpretation and structural measurements.
Advanced MR techniques offer superior insights into therapeutic effects, particularly on tumor microvasculature, but have historically faced challenges in multi-site consistency.

Purpose of the Study:

To review the benefits and drawbacks of incorporating advanced MR techniques into clinical trial protocols.
To detail the challenges of deploying these advanced techniques across diverse imaging centers.

Main Methods:

Review of existing literature and clinical trial methodologies.
Discussion of protocol design, site selection, training, and analysis standardization for advanced MR imaging.

Main Results:

Advanced MR techniques, such as dynamic contrast-enhanced MRI, can effectively measure changes in tumor blood flow and vascular permeability.
Recent efforts demonstrate that with meticulous planning and standardization, consistent and high-quality results are achievable across multiple sites, even with complex protocols.

Conclusions:

Advanced MR techniques are valuable for evaluating targeted therapeutics affecting tumor microvasculature.
Overcoming implementation challenges is key to leveraging these powerful tools in large-scale clinical trials across various research institutions and community imaging centers.