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Virological predictors of response to retreatment in hepatitis C genotype 2 infected patients

Chung-Feng Huang1, Chia-Yen Dai, Ming-Lun Yeh

  • 1Institute of Clinical Medicine, College of Medicine, Kaohsiung Medical University, Kaohsiung, Taiwan.

Plos One
|March 26, 2013
PubMed
Abstract

Insights

Retreatment with peginterferon/ribavirin is effective for hepatitis C virus genotype 2 (HCV-2) relapsers. Achieving an early virological response (EVR) is key for sustained virological response (SVR) in these patients.

Area of Science:

  • Hepatology
  • Virology
  • Genetics

Background:

  • Hepatitis C virus genotype 2 (HCV-2) retreatment outcomes are not well understood.
  • The role of virological factors and IL-28B rs8099917 genotype in HCV-2 retreatment is unclear.

Purpose of the Study:

  • To investigate the impact of virological factors and IL-28B rs8099917 genotype on retreatment outcomes in HCV-2 patients.
  • To evaluate the efficacy of peginterferon/ribavirin retreatment in treatment-experienced HCV-2 patients.

Main Methods:

  • 46 HCV-2 treatment-experienced patients (42 relapsers, 4 non-responders) were retreated with 24-week peginterferon/ribavirin.
  • On-treatment virological responses and IL-28B rs8099917 genotype were assessed.

Main Results:

  • The overall sustained virological response (SVR) rate was 71.7%.
  • Previous relapsers had significantly higher SVR rates (78.6%) compared to non-responders (0%).
  • Early virological response (EVR) was a strong predictor of SVR, particularly in relapsers.

Conclusions:

  • Peginterferon/ribavirin is effective for HCV-2 retreatment, especially for relapsers.
  • Achieving an EVR is crucial for predicting SVR in patients undergoing retreatment for HCV-2.

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