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Updated: May 13, 2026

Protocol to Create Chronic Wounds in Diabetic Mice
Published on: September 25, 2019
[Pathophysiology of healing]
Mar Pastor Armendáriz1, F Javier Domínguez Hernández, Pedro Bas Caro
1Unidad de Anestesia y Reanimación del Hospital Universitario Fundación de Alcorcón, Departamento de Enfermería Universidad Complutense, Madrid.
Abstract:
Treatment of wounds is part of the daily practice of the nursing staff and the knowledge of the physiology of healing, as well as modern treatment techniques are of great importance to provide the most effective and rapid healing method. The response of living tissues to injury constitutes the basis for understanding the process of healing. A reset of the total or partial integrity of tissues is part of a basic response. An alteration of the barrier of tissues can cause a loss of homeostasis generating a State of systemic hipermetabolism. Therefore, any wound caused a discontinuity of epithelium covering the body, triggers a cascade of events in a process to achieve that protection barrier will not disintegrate. These events will allow the regeneration of the tissue that has suffered the injury; forming a scar tissue that has the ability to maintain the barrier protection and support of the elements that it protects. Defined as scarring, to a natural repair process ofa wound by forming a scar. It is important to make a reminder of how you act reparative physiological mechanisms i.e. the cascade of healing processes, it is important to take into account these repair mechanisms to know the basis of how tissues work so you can assess and diagnose the alterations to this patient, in order to apply a right and proper treatment according to the needs of the patient.
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