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Related Concept Videos

Tandem Mass Spectrometry01:21

Tandem Mass Spectrometry

Tandem mass spectrometry is a technique that uses multiple mass analyzers in series to obtain a higher selectivity and reduce chemical noise during analyte detection. Instruments with multiple analyzers separated by an interaction cell enable secondary fragmentation and selected study of the fragment ions.Secondary fragmentations occur in the interaction cell and can be induced by various factors. Fragmentation induced by collision with inert gases, such as N2, Ar, He, etc., is called...
MALDI-TOF Mass Spectrometry01:19

MALDI-TOF Mass Spectrometry

Mass spectrometry is a powerful characterization technique that can identify and separate a wide variety of compounds ranging from chemical to biological entities, based on their mass-to-charge ratio (m/z). The instruments that allow this detection, known as mass spectrometers, have three components: an ion source, a mass analyzer, and a detector. These spectrometers differ based on the nature of their ion source and analyzers.Matrix-assisted laser desorption ionization (MALDI) is a commonly...
Electrospray Ionization (ESI) Mass Spectrometry01:12

Electrospray Ionization (ESI) Mass Spectrometry

Higher molecular weight biomolecules are nonvolatile compounds that may decompose before ionizing or vaporizing during mass analysis with conventional electron impact ionization methods. Accordingly, electrospray ionization (ESI) is the favored method for vaporizing and ionizing biomolecules as it circumvents rapid fragmentation and enables the recording of mass signals for the entire biomolecule.
ESI utilizes electrical energy to transfer ions from the liquid phase of the sample into the...
Mass Spectrometers01:16

Mass Spectrometers

This lesson details the instrumentation of a mass spectrometer—a physical instrument to perform mass spectrometry on analyte molecules and record the characteristic mass spectra. This is achieved via three chief functions:
Mass Spectrum: Interpretation01:24

Mass Spectrum: Interpretation

An unknown compound can be established by identifying the molecular ion peak in the mass spectrum. The molecular ion peak is often weak or absent due to the predominance of fragmentation in high-energy electron beams. In such cases, a soft-energy electron beam can be used to scan the spectrum to enhance the intensity of the molecular ion peak. Additionally, chemical ionization, field ionization, and desorption ionization spectra are used to obtain a relatively intense molecular ion peak.To...
Mass Spectrometry: Overview01:19

Mass Spectrometry: Overview

Mass spectrometry is an analytical technique used to determine the molecular mass and molecular formula of a compound. The basic principle of mass spectrometry is to generate ions from the analyte molecule and measure these ion abundances against their molecular mass. One common type of ionization, known as electron ionization or EI, bombards the analyte molecules in the gas phase with high-energy electron beams. The electron beams displace an electron from the molecule and leave behind a...

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Atmospheric-pressure Molecular Imaging of Biological Tissues and Biofilms by LAESI Mass Spectrometry
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Atmospheric-pressure Molecular Imaging of Biological Tissues and Biofilms by LAESI Mass Spectrometry

Published on: September 3, 2010

Environmental mass spectrometry.

Albert T Lebedev1

  • 1Organic Chemistry Department, M.V. Lomonosov Moscow State University, Moscow 119991, Russia. a.lebedev@org.chem.msu.ru

Annual Review of Analytical Chemistry (Palo Alto, Calif.)
|March 27, 2013
PubMed
Summary
This summary is machine-generated.

Environmental mass spectrometry is rapidly advancing, focusing on broader compound analysis and faster, high-throughput methods. Portable, affordable mass spectrometers could revolutionize analytical chemistry and become common household devices.

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Whole-body Mass Spectrometry Imaging by Infrared Matrix-assisted Laser Desorption Electrospray Ionization (IR-MALDESI)
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Area of Science:

  • Environmental mass spectrometry
  • Analytical chemistry

Background:

  • Environmental mass spectrometry is crucial for policy decisions impacting human and ecosystem health.
  • The field is experiencing rapid advancements and broadening analytical capabilities.

Purpose of the Study:

  • To highlight key directions in environmental mass spectrometry development.
  • To explore the potential impact of portable mass spectrometry technology.

Main Methods:

  • Broadening targeted and nontargeted compound analysis.
  • Increasing analytical reliability with accurate mass measurements, tandem mass spectrometry, and isotopically labeled standards.
  • Shifting towards high-throughput analysis with minimal sample preparation using ambient ionization and miniature instruments.

Main Results:

  • Significant broadening of targeted and nontargeted chemical analysis.
  • Enhanced analytical reliability through advanced techniques.
  • Development of faster, high-throughput methods with reduced sample preparation.

Conclusions:

  • Portable, sensitive, and robust mass spectrometers utilizing ambient ionization could revolutionize analytical chemistry.
  • Reduced costs for these instruments could lead to widespread adoption, even in households.