[A model of mononuclear phagocyte block using carrageenan-kappa]

Experiments conducted on CBA mice to study the effect of intraperitoneal injections of 1.0, 2.5, 5.0, and 10 mg/mouse of carrageenan-kappa (Sigma, USA) on the ingesting capacity of mononuclear phagocytes allowed the authors to suggest a model of 10- and 24-hour macrophage block. Doses of 2.5 and 5 mg/mouse are most advisable. Monocytopenia was encountered in peripheral blood in block of macrophages. The depth and duration of the macrophage block can be controlled according to the response of peripheral blood monocytes of mice given carrageenan-kappa.