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Single step bottom-up process to generate solid phospholipid nano-particles.

Ulla Brinkmann-Trettenes1, Sabine Barnert, Annette Bauer-Brandl

  • 1Institute of Physics, Chemistry and Pharmacy, University of Southern Denmark , Odense M , Denmark and.

Pharmaceutical Development and Technology
|March 27, 2013
PubMed
Summary
This summary is machine-generated.

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This study shows that a nano spray dryer can create solid phospholipid nanoparticles from crude dispersions below 10% concentration. These nanoparticles are suitable for pulmonary delivery and re-disperse into liposomes.

Area of Science:

  • Pharmaceutical Technology
  • Materials Science
  • Nanotechnology

Background:

  • The Nano Spray Dryer B-90 utilizes an ultrasonic frequency vibrating mesh nozzle.
  • Investigating crude phospholipid dispersions for nanoparticle formation is crucial for drug delivery.

Purpose of the Study:

  • To examine process parameters and processability of crude phospholipid dispersions.
  • To determine the effect of concentration and mesh aperture on nanoparticle size and re-dispersion.
  • To evaluate the suitability of spray-dried phospholipids for pulmonary applications.

Main Methods:

  • Spray drying of phospholipid dispersions stabilized with trehalose.
  • Analysis of dry powder particle size using Scanning Electron Microscopy (SEM).
  • Characterization of re-dispersed particles via Dynamic Light Scattering (PCS) and cryo-Transmission Electron Microscopy (cryo-TEM).

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Main Results:

  • Spray drying yielded solid phospholipid nanoparticles from crude liposome dispersions.
  • Increased nozzle mesh aperture and dispersion concentration led to larger nanoparticle sizes.
  • Processability limit for crude dispersions was found below 10% (m/m), but pre-sonication improved it.

Conclusions:

  • The nano spray dryer effectively produces solid phospholipid nanoparticles from crude dispersions (<10% m/m) for pulmonary delivery.
  • Re-dispersion of the spray-dried powder results in liposomes.
  • The study highlights the potential of nano spray drying for phospholipid-based formulations.