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Relation between serum thrombospondin-2 and cardiovascular mortality in older men screened for abdominal aortic

Jonathan Golledge1, Paula Clancy, Graeme J Hankey

  • 1Vascular Biology Unit, Queensland Research Centre for Peripheral Vascular Disease, School of Medicine and Dentistry, James Cook University, Townsville, Australia. jonathan.golledge@jcu.edu.au

The American Journal of Cardiology
|March 27, 2013
PubMed

Insights

Higher levels of serum thrombospondin-2 (TSP-2) are linked to increased cardiovascular mortality risk in older men. Serum TSP-2 concentration is an independent predictor of cardiac mortality, while TSP-1 showed no association.

Area of Science:

  • Cardiovascular Medicine
  • Biomarkers
  • Gerontology

Background:

  • Thrombospondin-1 and -2 (TSP-1, TSP-2) play roles in angiogenesis, thrombosis, and inflammation, processes critical to cardiovascular disease pathogenesis.
  • Understanding biomarkers for cardiovascular risk is crucial for preventative strategies in aging populations.

Purpose of the Study:

  • To investigate the association between serum concentrations of TSP-1 and TSP-2 and the risk of cardiovascular mortality in elderly men.
  • To determine if TSP-1 and TSP-2 can serve as independent predictors of cardiovascular events in this demographic.

Main Methods:

  • A cohort study of 992 elderly men recruited between 2001-2004.
  • Serum TSP-1 and TSP-2 levels were measured using immunoassay.
  • Follow-up until 2009 using the Western Australia Data Linkage System, with survival analysis (Kaplan-Meier, Cox proportional hazards).

Main Results:

  • Serum TSP-2 concentration was strongly associated with all-cause and cardiovascular mortality.
  • Men in the highest quartile of serum TSP-2 had a significantly increased risk of cardiovascular mortality (3.37-fold).
  • Serum TSP-2 was independently associated with cardiac mortality, with a 3.55-fold increased risk for the highest quartile.

Conclusions:

  • Elevated serum TSP-2 levels are an independent and significant risk factor for cardiac mortality in older men.
  • Serum TSP-1 concentration was not found to be associated with cardiovascular mortality in this cohort.
  • TSP-2 emerges as a potential biomarker for predicting cardiac mortality risk in elderly males.

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