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Increased pulse-wave velocity and carotid intima-media thickness in patients with lower urinary tract symptoms

Hakki Uzun1, Yüksel Çiçek, Sinan Altan Kocaman

  • 1Departments of Urology, School of Medicine, Recep Tayyip Erdoğan University , Rize , Turkey.

Scandinavian Journal of Urology
|March 27, 2013
PubMed

Insights

Vascular impairment, including arterial stiffness and atherosclerosis, is significantly associated with lower urinary tract symptoms (LUTS) in men and overactive bladder (OAB) in women. These findings suggest a link between vascular health and urinary dysfunction.

Area of Science:

  • Urology
  • Cardiology
  • Vascular Medicine

Background:

  • Lower urinary tract symptoms (LUTS) in men and overactive bladder (OAB) in women often coexist with vascular risk factors.
  • Atherosclerosis and endothelial dysfunction are implicated in LUTS development.
  • Arterial stiffness, indicated by decreased arterial compliance, and carotid intima-media thickness (CIMT) are markers of vascular aging and impairment.

Purpose of the Study:

  • To investigate the association between arterial stiffness and vascular atherosclerotic changes with LUTS in men and OAB in women.
  • To explore the role of vascular health in the pathophysiology of lower urinary tract symptoms.

Main Methods:

  • Prospective, cross-sectional study of 66 patients with LUTS/OAB and 62 controls.
  • Carotid-femoral pulse-wave velocity (CF-PWV) measured as an index of arterial stiffness.
  • Carotid intima-media thickness (CIMT) measured via B-mode ultrasonography to assess vascular impairment.

Main Results:

  • Patients with LUTS/OAB exhibited significantly higher CF-PWV and CIMT compared to controls (p < 0.001 for both).
  • Age and glucose levels were also significantly different between groups.
  • Multivariate analyses confirmed that both CIMT and PWV were independently related to LUTS (p < 0.001).

Conclusions:

  • Vascular impairment, including arterial stiffness and atherosclerosis, is significantly associated with LUTS in both men and women.
  • Atherosclerosis-related vascular risk factors may share pathogenic pathways with LUTS.
  • These findings highlight potential interactions between vascular health and urinary dysfunction.
Abstract

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