Search research articles

ABOUT JoVE

Overview Leadership Blog JoVE Help Center

AUTHORS

Publishing Process Editorial Board Scope & Policies Peer Review FAQ Submit

LIBRARIANS

Testimonials Subscriptions Access Resources Library Advisory Board FAQ

RESEARCH

JoVE Journal Methods Collections JoVE Encyclopedia of Experiments Archive

EDUCATION

JoVE Core JoVE Business JoVE Science Education JoVE Lab Manual Faculty Resource Center Faculty Site

Terms & Conditions of Use

Related Concept Videos

Three-Compartment Open Model

Three-Compartment Open Model

The three-compartment open model is a pharmacokinetic model used to describe the distribution and elimination of drugs following extravascular administration. It comprises a central compartment representing the plasma and two peripheral compartments. The highly perfused peripheral compartment represents organs and tissues with a rich blood supply, such as the liver, kidneys, and lungs. The scarcely perfused peripheral compartment represents tissues with lower blood supply, such as adipose...

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by

Same author

E. coli Extracellular Matrix: A Tunable Composite With Hierarchical Structure.

Advanced materials (Deerfield Beach, Fla.)·2026

Same author

Shaping tissues with defects.

Science (New York, N.Y.)·2026

Same author

Cortical tension links curvature to tissue growth in the cellular Potts model.

Physical review. E·2026

Same author

Associations of cigarette smoking with coronary artery and extra-coronary calcification in older adults: The Atherosclerosis Risk in Communities study.

Atherosclerosis·2026

Same author

Zinc and hydroxyapatite co-localize during in vitro E. coli biofilms mineralization.

Scientific reports·2026

Same author

Supine hypertension and cardiovascular disease: controversies and advances.

Future cardiology·2025

Same journal

Analysis of typical cases of medical infusion pump metering acceptance in nursing scenarios.

Computer methods in biomechanics and biomedical engineering·2026

Same journal

Investigation of biomechanical effect of inverted orthotic insoles on flexible flatfeet.

Computer methods in biomechanics and biomedical engineering·2026

Same journal

FeuNet: cross-user gesture recognition and fingertip force estimation network based on feature enhancement and U-Net.

Computer methods in biomechanics and biomedical engineering·2026

Same journal

Both chronological age and individual differences in aging are the two indispensable components for predicting biological age.

Computer methods in biomechanics and biomedical engineering·2026

Same journal

Effects of restraint tether devices on pilots' neck injuries under arrested landing conditions.

Computer methods in biomechanics and biomedical engineering·2026

Same journal

Advancing cardiac health assessment using deep convolutional neural networks for ECG image analysis.

Computer methods in biomechanics and biomedical engineering·2026

See all related articles

Search research articles

Related Experiment Video

Updated: May 13, 2026

Engineering Three-dimensional Epithelial Tissues Embedded within Extracellular Matrix

Engineering Three-dimensional Epithelial Tissues Embedded within Extracellular Matrix

Published on: July 10, 2016

A three-dimensional model for tissue deposition on complex surfaces.

Cécile M Bidan¹, Frances M Wang, John W C Dunlop

¹a Department of Biomaterials , Max Planck Institute of Colloids and Interfaces , 14424 , Potsdam , Germany.

Computer Methods in Biomechanics and Biomedical Engineering

|March 27, 2013

Summary

This summary is machine-generated.

This study extends a 2D model of curvature-driven growth to 3D, simulating tissue behavior and cell migration. The findings offer insights into how surface curvature influences biological processes like morphogenesis and bone healing.

More Related Videos

Generation of a Simplified Three-Dimensional Skin-on-a-chip Model in a Micromachined Microfluidic Platform

Generation of a Simplified Three-Dimensional Skin-on-a-chip Model in a Micromachined Microfluidic Platform

Published on: May 17, 2021

Multimodal 3D Printing of Phantoms to Simulate Biological Tissue

Multimodal 3D Printing of Phantoms to Simulate Biological Tissue

Published on: January 11, 2020

Related Experiment Videos

Last Updated: May 13, 2026

Engineering Three-dimensional Epithelial Tissues Embedded within Extracellular Matrix

Engineering Three-dimensional Epithelial Tissues Embedded within Extracellular Matrix

Published on: July 10, 2016

Generation of a Simplified Three-Dimensional Skin-on-a-chip Model in a Micromachined Microfluidic Platform

Generation of a Simplified Three-Dimensional Skin-on-a-chip Model in a Micromachined Microfluidic Platform

Published on: May 17, 2021

Multimodal 3D Printing of Phantoms to Simulate Biological Tissue

Multimodal 3D Printing of Phantoms to Simulate Biological Tissue

Published on: January 11, 2020

Area of Science:

Biophysics
Developmental Biology
Computational Biology

Background:

Biological processes are influenced by environmental physical properties, including geometry.
Tissue patterning is regulated by geometry-driven growth and material properties affecting shape.
Existing 2D models show promise in explaining tissue patterning control.

Purpose of the Study:

To extend a 2D digital model of curvature-driven growth to three dimensions (3D).
To incorporate cell migration into the model for simulating in vitro 3D systems.
To evaluate the model's applicability to computed tomography (CT) data.

Main Methods:

Development of a 3D digital model based on a 2D curvature-driven growth model.
Simulation using artificial geometries to test model relevance and precision.
Integration of cell migration algorithms to enhance simulation accuracy.

Main Results:

Successful extension of the 2D model to a 3D computational framework.
Validation of the model's precision and relevance using artificial geometries.
Demonstration of cell migration implementation for improved in vitro 3D system simulation.

Conclusions:

The 3D model provides a robust tool for simulating curvature-driven biological processes.
This model can be applied to analyze computed tomography data.
Understanding surface curvature's role in morphogenesis, growth, and bone regeneration is enhanced.