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Updated: May 13, 2026

Optical Coherence Tomography Based Biomechanical Fluid-Structure Interaction Analysis of Coronary Atherosclerosis Progression
Published on: January 15, 2022
Iatrogenic coronary ostial stenosis of left main stem following aortic valve replacement: visualization with optical
Muhammad A Khan1, Francesco Prati, Magdi El-Omar
1Department of Cardiology, Manchester Heart Centre, Manchester Royal Infirmary, M13 9WL Manchester, United Kingdom.
Insights
Iatrogenic coronary ostial stenosis, a rare complication after aortic valve replacement (AVR), can occur due to cannula trauma during cardioplegia delivery. This case highlights the importance of surgical awareness for preventing this serious post-operative issue.
Area of Science:
- Cardiovascular Surgery
- Interventional Cardiology
- Cardiac Imaging
Background:
- Iatrogenic coronary ostial stenosis is a recognized complication following aortic valve replacement (AVR).
- It typically manifests within six months of the surgical procedure.
- The incidence rate can be as high as 3.4% in affected patients.
Observation:
- An 85-year-old male presented with acute coronary syndrome two months post-AVR.
- Coronary angiography identified a severe de novo lesion in the left main coronary artery.
- Optical coherence tomography (OCT) revealed severe intimal hyperplasia as the cause of the stenosis.
Findings:
- The observed intimal hyperplasia suggests a mechanism of vessel wall trauma.
- The trauma is likely attributed to the rigid tip of the cannula used for antegrade cardioplegia administration.
- This represents a specific iatrogenic cause of coronary ostial stenosis post-AVR.
Implications:
- Surgeons must exercise caution when administering cardioplegia solution via the antegrade approach.
- Awareness of this potential complication can guide surgical technique to minimize risk.
- Early recognition and understanding of this mechanism are crucial for patient outcomes after AVR.
Abstract:
Iatrogenic coronary ostial stenosis following aortic valve replacement (AVR) occurs in up to 3.4% of cases and usually presents within the first 6months following surgery. We present the case of an 85year old man who developed an acute coronary syndrome 2months following AVR. Coronary angiography revealed a severe de novo lesion in the left main stem, which, on optical coherence tomography, was shown to be due to severe intimal hyperplasia. The most likely underlying mechanism is vessel wall trauma caused by the rigid tip cannula used for administration of cardioplegia solution. Surgeons should be aware of this possibility when administering this solution via the antegrade approach.
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