Related Experiment Video
Updated: May 12, 2026
Zebrafish Model of Neuroblastoma Metastasis
Published on: March 14, 2021
Management of stage 4S composite neuroblastoma with a MYCN-amplified nodule
Michael W Bishop1, Hong Yin, Hiroyuki Shimada
1*Division of Hematology/Oncology †Division of Pathology §Department of Radiology ∥Division of Gastroenterology, Cincinnati Children's Hospital Medical Center, Cincinnati, OH ‡Department of Pathology and Laboratory Medicine, Children's Hospital Los Angeles, University of Southern California, Los Angeles, CA.
Abstract:
MYCN amplification in neuroblastoma is usually associated with a poor prognosis. Very few cases of heterogenous MYCN amplification have been previously reported, and the clinical significance of heterogeneity is unclear. We report a neonate with an adrenal stage 4S neuroblastoma with a small focus of MYCN-amplified cells within a nonamplified background. After adrenalectomy, the patient has been observed without use of chemotherapy and has no evidence of disease progression.
