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Anthelminthic Agents

Anthelminthic Agents

Anthelmintic drugs differ significantly from antiparasitic therapies targeting protozoa, primarily due to differences in parasite biology. Whereas most protozoal treatments act on proliferating cells, anthelmintics are typically directed against mature, nonproliferative helminths. The therapeutic approach considers the helminth's reliance on neuromuscular coordination, glucose metabolism, and microtubular integrity for survival, reproduction, and localization within the host. Most anthelmintics...

Targets for Drug Action: Overview

Targets for Drug Action: Overview

Drugs target macromolecules to modify ongoing cellular processes. Primary drug targets include receptors, ion channels, transporters, and enzymes.
Receptors are either membrane-spanning or intracellular proteins, which upon binding a ligand, get activated and transmit the signal downstream to elicit a response. Drugs bind receptors, either mimicking the action of endogenous ligands or blocking the receptor activity to bring about a modified response. Nearly 35% of approved drugs target the G...

Pharmacogenomics: Identification of New Drug Targets

Pharmacogenomics: Identification of New Drug Targets

Advances in genomics have profoundly influenced drug discovery by increasing both the speed and accuracy of pharmaceutical development. Pharmacogenomics, which examines how genetic variation influences drug response, facilitates the identification of novel therapeutic targets and enables patient stratification for personalized treatment. These strategies contribute to improved drug efficacy, minimized adverse effects, and more efficient clinical trial design.Mapping genetic differences...

Pharmacogenetics of Drug Targets: β₂-Adrenergic Receptors, Apo E, Thymidylate Synthase

Pharmacogenetics of Drug Targets: β₂-Adrenergic Receptors, Apo E, Thymidylate Synthase

Genetic polymorphisms in drug targets have emerged as critical determinants of interindividual variability in drug response and toxicity. Pharmacogenomic investigations increasingly focus on identifying these variations to personalize and optimize therapeutic interventions. A drug target may be a receptor, enzyme, or signaling protein involved in pharmacologic responses or disease-related pathways. While early pharmacogenetic studies focused primarily on drug metabolism, current research...

Drug Discovery: Overview

Drug Discovery: Overview

Drug discovery is a multifaceted process involving extensive screening, testing, and optimization of lead compounds to identify potential new drugs for therapeutic use. It combines several approaches, including screening large numbers of natural products, chemical modification of known active molecules, identification of new drug targets, and rational design based on biological mechanisms and drug-receptor structure. These approaches are carried out in both academic research laboratories and...

Targeted Cancer Therapies

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Updated: May 12, 2026

Cultivation of Heligmosomoides Polygyrus: An Immunomodulatory Nematode Parasite and its Secreted Products

Cultivation of Heligmosomoides Polygyrus: An Immunomodulatory Nematode Parasite and its Secreted Products

Published on: April 6, 2015

Current drug targets for helminthic diseases.

Ajay Kumar Rana¹, Shailja Misra-Bhattacharya

¹CSIR-Central Drug Research Institute, BS 10/1, Jankipuram Extension, Sitapur Road, Lucknow, 226001, India.

Parasitology Research

|March 27, 2013

Summary

Drug resistance in helminth parasites necessitates new treatments. This review details advances in helminth drug target discovery, identifying potential targets for human and livestock diseases like schistosomiasis.

Area of Science:

Parasitology
Drug Discovery
Molecular Biology

Background:

Over 2 billion people globally are infected with helminth parasites.
Increasing anthelmintic drug resistance in human and livestock helminths demands urgent solutions.
Key helminthic diseases include schistosomiasis, onchocerciasis, and lymphatic filariasis.

Purpose of the Study:

To review recent advancements in helminth drug target discovery.
To identify and document potential drug targets for economically important helminth species.
To combat widespread helminthic diseases in humans and livestock.

Main Methods:

Genomic and proteomic analyses.
Biochemical and biophysical investigations.
In vitro and in vivo experimental studies in animal models.

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Published on: August 22, 2012

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Cultivation of Heligmosomoides Polygyrus: An Immunomodulatory Nematode Parasite and its Secreted Products

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Published on: April 6, 2015

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Published on: August 22, 2012

In silico search and prioritization of genome-scale functional datasets.

Main Results:

Identification of numerous potential drug targets across various helminth species.
Systematic documentation of drug targets for human and livestock parasites.
Leveraging genomic data to guide experimental drug discovery efforts.

Conclusions:

Advances in omics and experimental approaches are crucial for helminth drug target discovery.
A curated list of drug targets can accelerate the development of new anthelmintics.
Effective new drugs are needed for physicians and veterinarians to control helminth infections.