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Multi-electrode Array Recordings of Human Epileptic Postoperative Cortical Tissue
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M-Current Recording from Acute DRG Slices.

Kirstin E Rose1, Sylvain Gigout, Nikita Gamper

  • 1Faculty of Biological Sciences, School of Biomedical Sciences, University of Leeds, Leeds, UK.

Methods in Molecular Biology (Clifton, N.J.)
|March 27, 2013
PubMed
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Researchers developed a new method for patch-clamp recordings in rat dorsal root ganglion (DRG) slices. This technique allows for studying peripheral nervous system excitability under physiological conditions.

Area of Science:

  • Neuroscience
  • Physiology

Background:

  • Electrophysiological recordings offer insights into neuronal function.
  • Studying peripheral nervous system neurons in acute preparations is challenging.

Purpose of the Study:

  • To establish a reliable method for patch-clamp recordings from dorsal root ganglion (DRG) slices.
  • To enable the study of peripheral nervous system excitability in native neurons.

Main Methods:

  • Developed a technique for preparing acute slices of rat dorsal root ganglia.
  • Utilized patch-clamp electrophysiology to record from neurons within these slices.

Main Results:

  • Successfully performed patch-clamp recordings from rat DRG slices.
  • Demonstrated the feasibility of studying ionic currents and neuronal excitability in this preparation.

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Related Experiment Videos

Last Updated: May 12, 2026

Multi-electrode Array Recordings of Human Epileptic Postoperative Cortical Tissue
13:14

Multi-electrode Array Recordings of Human Epileptic Postoperative Cortical Tissue

Published on: October 26, 2014

Recording Network Activity in Spinal Nociceptive Circuits Using Microelectrode Arrays
11:28

Recording Network Activity in Spinal Nociceptive Circuits Using Microelectrode Arrays

Published on: February 9, 2022

Acute Mouse Brain Slicing to Investigate Spontaneous Hippocampal Network Activity
07:58

Acute Mouse Brain Slicing to Investigate Spontaneous Hippocampal Network Activity

Published on: August 28, 2020

Conclusions:

  • The described method facilitates electrophysiological studies of peripheral sensory neurons.
  • This approach provides a valuable tool for investigating DRG neuron function under near physiological conditions.