Search research articles

ABOUT JoVE

Overview Leadership Blog JoVE Help Center

AUTHORS

Publishing Process Editorial Board Scope & Policies Peer Review FAQ Submit

LIBRARIANS

Testimonials Subscriptions Access Resources Library Advisory Board FAQ

RESEARCH

JoVE Journal Methods Collections JoVE Encyclopedia of Experiments Archive

EDUCATION

JoVE Core JoVE Business JoVE Science Education JoVE Lab Manual Faculty Resource Center Faculty Site

Terms & Conditions of Use

Related Concept Videos

Acne Infection

Acne Infection

Acne is a multifactorial skin condition primarily affecting adolescents and young adults, with a global prevalence estimated to exceed 75% in this demographic. The condition is characterized by the formation of comedones (blackheads and whiteheads), papules, pustules, nodules, and, in severe cases, cysts, particularly in areas rich in sebaceous glands such as the face, neck, chest, and back. The pathogenesis involves increased sebum production, follicular hyperkeratinization, colonization by...

Accessory Structures of the Skin: Sebaceous Glands

Accessory Structures of the Skin: Sebaceous Glands

A sebaceous gland is a type of oil gland found almost all over the skin ( except palms and soles) and helps lubricate and waterproof the skin and hair. Most sebaceous glands are associated with hair follicles. They generate and excrete sebum, a mixture of lipids, onto the skin surface, thereby naturally lubricating the dry and dead layer of keratinized cells of the stratum corneum, keeping it pliable.
These glands that produce the oils on the skin and hair are holocrine glands. The mature...

The Skin Microbiota

The Skin Microbiota

The human skin serves as a complex ecosystem inhabited by a diverse community of microorganisms, including bacteria, fungi, and viruses. This microbiome plays a critical role in maintaining skin health and defending against pathogenic invaders. The composition of microbial communities varies significantly across different regions of the body, influenced primarily by the local levels of moisture and sebum.Regional Variation in Skin MicrobiotaCutibacterium acnes predominantly colonizes sebaceous...

Inflammatory Bowel Disease III: Diagnostic Studies and Management I-Nutritional Therapy

Inflammatory Bowel Disease III: Diagnostic Studies and Management I-Nutritional Therapy

Various diagnostic tests are employed in the diagnostic process for Inflammatory Bowel Disease (IBD), particularly to differentiate between Crohn's disease and ulcerative colitis.
Diagnostic studies
A colonoscopy is the definitive screening test, distinguishing ulcerative colitis from other colon diseases with similar symptoms. During a colonoscopy test, inflamed mucosa with exudate ulcerations can be observed, and biopsies are taken to determine the histologic characteristics of the colonic...

Dietary Connections

Dietary Connections

In biological systems, most metabolic pathways are interconnected. The cellular respiration processes that convert glucose to ATP—such as glycolysis, pyruvate oxidation, and the citric acid cycle—tie into those that break down other organic compounds. As a result, various foods—from apples to cheese to guacamole—end up as ATP. In addition to carbohydrates, food also contains proteins and lipids—such as cholesterol and fats. All of these organic compounds are used as energy sources to produce...

Atherosclerosis III: Management

Atherosclerosis III: Management

Management of atherosclerosis involves an integrated strategy encompassing pharmacological treatment, surgical interventions, lifestyle changes, and nutrition therapy to address the multifactorial nature of the disease.Pharmacological TherapyA cornerstone of atherosclerosis management is the use of pharmacological agents. Statins, such as atorvastatin, are pivotal in inhibiting HMG-CoA reductase, an enzyme that catalyzes an initial step in cholesterol synthesis in the liver. This reduction in...

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by

Same author

Isotretinoin's paradoxical effects in immortalized sebocytes.

The British journal of dermatology·2018

Same author

mTORC1 at the crossroad of metabolism and immunity in hidradenitis suppurativa.

Journal of the European Academy of Dermatology and Venereology : JEADV·2018

Same author

T helper 17 cell/regulatory T-cell imbalance in hidradenitis suppurativa/acne inversa: the link to hair follicle dissection, obesity, smoking and autoimmune comorbidities.

The British journal of dermatology·2018

Same author

Acne vulgaris: an inflammasomopathy of the sebaceous follicle induced by deviated FoxO1/mTORC1 signalling.

The British journal of dermatology·2016

Same author

Impaired Notch signalling: the unifying mechanism explaining the pathogenesis of hidradenitis suppurativa (acne inversa).

The British journal of dermatology·2012

Same author

Acne-associated syndromes: models for better understanding of acne pathogenesis.

Journal of the European Academy of Dermatology and Venereology : JEADV·2011

Search research articles

Related Experiment Video

Updated: May 12, 2026

A Rat Model of Compound Acne

A Rat Model of Compound Acne

Published on: November 1, 2024

[Acne and diet].

¹Dermatologie, Umweltmedizin und Gesundheitstheorie, Universität Osnabrück. melnik@t-online.de

Der Hautarzt; Zeitschrift Fur Dermatologie, Venerologie, Und Verwandte Gebiete

|March 27, 2013

Summary

A Western diet, high in sugar and dairy, can worsen acne by activating mTORC1. A Palaeolithic-like diet may help manage acne by reducing this pathway.

Area of Science:

Dermatology
Nutrition Science
Cellular Biology

Background:

Acne vulgaris is a prevalent skin condition in industrialized nations, particularly affecting adolescents and young adults.
It is increasingly linked to lifestyle factors such as increased body mass index and insulin resistance.
The "Western diet," characterized by high glycemic load and dairy consumption, is implicated in acne pathogenesis.

Purpose of the Study:

To explore the role of nutrient-sensing pathways in acne development.
To investigate the mechanistic link between diet, metabolic signaling, and acne.
To propose dietary interventions for acne management based on cellular signaling pathways.

Main Methods:

The study reviews the role of the metabolic transcription factor FoxO1 and the kinase mTORC1 in integrating nutrient signals.

More Related Videos

Influence of Emotional Factors on the Efficacy of Acupuncture Treatment for Overweight Complicated with Hyperlipidemia: A Retrospective Cohort Study

Influence of Emotional Factors on the Efficacy of Acupuncture Treatment for Overweight Complicated with Hyperlipidemia: A Retrospective Cohort Study

Published on: November 21, 2025

An Acupoint Catgut-embedding Therapy for Treating Obesity

An Acupoint Catgut-embedding Therapy for Treating Obesity

Published on: April 4, 2025

Related Experiment Videos

Last Updated: May 12, 2026

A Rat Model of Compound Acne

A Rat Model of Compound Acne

Published on: November 1, 2024

Influence of Emotional Factors on the Efficacy of Acupuncture Treatment for Overweight Complicated with Hyperlipidemia: A Retrospective Cohort Study

Influence of Emotional Factors on the Efficacy of Acupuncture Treatment for Overweight Complicated with Hyperlipidemia: A Retrospective Cohort Study

Published on: November 21, 2025

An Acupoint Catgut-embedding Therapy for Treating Obesity

An Acupoint Catgut-embedding Therapy for Treating Obesity

Published on: April 4, 2025

It examines how insulin, IGF-1, and branched-chain amino acids, particularly leucine, activate mTORC1.

The research analyzes the impact of Western diet components on mTORC1 activity.

Main Results:

Overactivation of mTORC1, a key regulator of cell growth and biosynthesis, is a central mechanism in diet-induced acne.
Insulin, IGF-1, and leucine in the Western diet contribute to mTORC1 activation.
Reduced glycemic load and decreased consumption of milk products are identified as key dietary modifications.

Conclusions:

Understanding nutrient signaling and mTORC1 activation provides a rationale for dietary acne interventions.
A Palaeolithic-like diet, emphasizing vegetables and fish while reducing sugars, refined grains, and dairy, may attenuate mTORC1 activity.
Dietary modulation targeting mTORC1 offers a promising approach for managing acne vulgaris.