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Surface Enhanced Raman Spectroscopy Detection of Biomolecules Using EBL Fabricated Nanostructured Substrates

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Graphene: a platform for surface-enhanced Raman spectroscopy.

Weigao Xu¹, Nannan Mao, Jin Zhang

¹Center for Nanochemistry, Beijing National Laboratory for Molecular Sciences, Key Laboratory for the Physics and Chemistry of Nanodevices, State Key Laboratory for Structural Chemistry of Unstable and Stable Species, College of Chemistry and Molecular Engineering, Peking University, Beijing 100871, China.

Small (Weinheim an Der Bergstrasse, Germany)

|March 27, 2013

Summary

Graphene enhances surface-enhanced Raman spectroscopy (SERS) for single-molecule detection, improving reproducibility and enabling practical applications. This review explores graphene

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Area of Science:

Analytical Chemistry
Materials Science
Spectroscopy

Background:

Surface-enhanced Raman spectroscopy (SERS) offers single-molecule detection capabilities.
Current SERS methods face challenges with signal reproducibility and practical applicability.
Graphene's unique properties present a novel platform for SERS advancement.

Purpose of the Study:

To review the diverse roles of graphene in surface-enhanced Raman spectroscopy.
To highlight graphene's contribution to improving SERS performance and applications.
To explore how graphene-based SERS can elucidate the fundamental SERS mechanism.

Main Methods:

Review of existing literature on graphene in SERS.
Analysis of graphene's functions as a Raman probe, substrate, additive, and building block.
Examination of SERS performance enhancements and mechanistic insights.

Main Results:

Graphene acts as a versatile component in SERS systems.
Graphene integration significantly improves SERS performance for various applications.
Graphene-based SERS studies offer new perspectives on the SERS effect mechanism.

Conclusions:

Graphene is a promising material for overcoming current limitations in SERS.
The multifaceted roles of graphene are crucial for advancing SERS technology.
Further research into graphene-involved SERS is essential for both practical applications and fundamental understanding.