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Related Experiment Videos

Virus safe plasma exchange medium containing essential human plasma proteins.

R Kotitschke1, W Stephan, R Lissner

  • 1Biotest Pharma GmbH, Frankfurt/Main.

Progress in Clinical and Biological Research
|January 1, 1990
PubMed
Summary

Coagulation Factor Free Plasma (CFFP) offers a safer alternative to Fresh Frozen Plasma (FFP), minimizing viral transmission risks. It serves as an advantageous plasma exchange solution, preserving normal plasma constituents.

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Area of Science:

  • Biotechnology
  • Hematology
  • Plasma Products

Background:

  • Fresh Frozen Plasma (FFP) carries risks of viral disease transmission.
  • Albumin and FFP can lead to depletions of normal plasma constituents during plasma exchange.

Purpose of the Study:

  • To introduce Coagulation Factor Free Plasma (CFFP) as a superior plasma exchange solution.
  • To highlight the safety and efficacy advantages of CFFP over FFP and albumin.

Main Methods:

  • CFFP is manufactured from pooled human plasma (>1000 donors/lot) under standardized conditions.
  • Sterilization is achieved using beta-PL/UV treatment.

Main Results:

  • CFFP avoids the viral transmission risks associated with FFP.

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  • CFFP prevents the depletion or deviation of normal plasma constituents seen with other solutions.
  • Conclusions:

    • CFFP presents a safer and more effective option for plasma exchange.
    • CFFP maintains the integrity of plasma components, offering clinical benefits.