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Related Concept Videos

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Intelligence is often thought to be linked to brain size, but the relationship is more complex than that. While brain size does correlate modestly with some abilities, like verbal skills, the connection is weaker for others, such as spatial reasoning. Other factors, like brain structure, also play crucial roles. For instance, despite Einstein's smaller-than-average brain, his parietal cortex, which is involved in spatial reasoning, was 15% wider, suggesting that neural density might matter more...
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Related Experiment Video

Updated: May 12, 2026

Rapid Fractionation and Isolation of Whole Blood Components in Samples Obtained from a Community-based Setting
11:31

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Published on: November 30, 2015

Infectious burden and cognitive function: the Northern Manhattan Study.

Mira Katan1, Yeseon Park Moon, Myunghee Cho Paik

  • 1Department of Neurology, Columbia University College of Physicians and Surgeons, New York, NY, USA. mk3270@columbia.edu

Neurology
|March 27, 2013
PubMed
Summary
This summary is machine-generated.

Infectious burden (IB), a measure of past infections, was linked to poorer cognitive performance in a multiethnic cohort. This suggests infections may play a role in cognitive impairment.

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Area of Science:

  • Neurology
  • Infectious Disease Epidemiology
  • Cognitive Science

Background:

  • Vascular risk factors are associated with cognitive decline.
  • Infectious burden (IB), a serologic measure of exposure to common pathogens, is linked to vascular risk.

Purpose of the Study:

  • To investigate the association between infectious burden (IB) and cognitive performance.
  • To determine if IB is associated with cognitive impairment in a multiethnic cohort.

Main Methods:

  • Cognition assessed using Mini-Mental State Examination (MMSE) and Telephone Interview for Cognitive Status (TICS-m).
  • Adjusted linear, logistic regressions, and generalized estimating equation models used to analyze associations between IB and cognitive measures.

Main Results:

  • Higher IB was associated with worse cognitive performance (MMSE and TICS-m).
  • IB was associated with a higher likelihood of MMSE ≤24 (indicating cognitive impairment).
  • IB was not associated with cognitive decline over time.

Conclusions:

  • Infectious burden is independently associated with cognitive performance in a multiethnic cohort.
  • Past infections may contribute to cognitive impairment.