Related Experiment Video

Updated: May 12, 2026

Isolation and Adoptive Transfer of High Salt Treated Antigen-presenting Dendritic Cells
09:29

Isolation and Adoptive Transfer of High Salt Treated Antigen-presenting Dendritic Cells

Published on: March 5, 2019

[The cell immunity in patients with arterial hypertension and obesity]

É N Trushina, O K Mustafina, S Kh Soto

    Voprosy Pitaniia
    |March 28, 2013
    PubMed

    Insights

    Patients with arterial hypertension and obesity show increased activated T-lymphocytes and higher CD95-antigen expression. This indicates heightened T-cell immunity and a correlation with body mass index in these individuals.

    Area of Science:

    • Immunology
    • Cardiovascular disease research
    • Metabolic disease research

    Context:

    • Arterial hypertension and obesity are significant global health concerns.
    • Immune system dysregulation is increasingly linked to these conditions.
    • Understanding lymphocyte subpopulations and activation markers is crucial for disease insight.

    Purpose:

    • To investigate lymphocyte subpopulations, including activated T-lymphocytes and CD95-antigen expression, in patients with arterial hypertension and obesity.
    • To compare these immune parameters with those of healthy individuals.
    • To explore correlations between immune markers and body mass index.

    Summary:

    • Flow cytometry analysis revealed an elevated immunoregulatory index (T-helper to cytotoxic T-lymphocyte ratio) in patients.
    • Increased levels of activated T-lymphocytes (CD3+CD25+, CD3+HLA-DR+) and Natural Killer T-cells (NKT-cells) were observed.
    • Higher CD95-antigen expression on lymphocytes was noted in patients compared to controls.
    • A direct correlation was found between increased T-helper cells, activated T-lymphocytes, NKT-cells, CD95-antigen expression, and body mass index.

    Impact:

    • Findings suggest enhanced T-cell immunity and altered lymphocyte profiles in arterial hypertension and obesity.
    • The study highlights potential immune-based biomarkers for these conditions.
    • Results provide a basis for further research into immune system modulation for managing hypertension and obesity.

    More Related Videos

    Visualizing Leukocyte Rolling and Adhesion in Angiotensin II-Infused Mice: Techniques and Pitfalls10:16

    Visualizing Leukocyte Rolling and Adhesion in Angiotensin II-Infused Mice: Techniques and Pitfalls

    Published on: January 4, 2018

    Characterization of Immune Cells in Human Adipose Tissue by Using Flow Cytometry07:32

    Characterization of Immune Cells in Human Adipose Tissue by Using Flow Cytometry

    Published on: March 6, 2018

    Related Concept Videos

    Hypertension II: Pathophysiology01:29

    Hypertension II: Pathophysiology

    Hypertension is a chronic condition in which the blood's force against artery walls is excessively high, posing risks such as heart disease. The condition's underlying mechanisms involve complex interactions among the cardiovascular, kidney, and autonomic nervous systems.Renin-Angiotensin-Aldosterone System (RAAS): This system significantly influences blood pressure regulation. When blood pressure decreases, the kidneys secrete renin. This enzyme transforms angiotensinogen, a plasma protein,...
    Antihypertensive Drugs: Angiotensin II Receptor Blockers01:30

    Antihypertensive Drugs: Angiotensin II Receptor Blockers

    In the renin-angiotensin-aldosterone system, a hormone called angiotensin II plays a crucial role. It binds to the AT1 receptors in vascular smooth muscles coupled with Gq proteins. The activation of these receptors activates an enzyme called phospholipase C, which releases two molecules: inositol trisphosphate and diacylglycerol. These molecules cause a chain reaction that leads to the phosphorylation of myosin light chains and promotes interaction between actin and myosin, leading to smooth...
    Hypertension and Regulation of Blood Pressure01:18

    Hypertension and Regulation of Blood Pressure

    Hypertension, the most common cardiovascular disease, is diagnosed through repeated measurements of elevated blood pressure. Its risks, including damage to the kidney, heart, and brain, are directly proportional to blood pressure levels. Starting from 115/75 mm Hg, the risk of cardiovascular disease doubles with each increment of 20/10 mm Hg. The diagnosis relies on blood pressure measurements, not on patient symptoms, as hypertension is often asymptomatic until end-organ damage is imminent or...
    Hypertension III: Clinical Manifestations and Diagnostic Studies01:30

    Hypertension III: Clinical Manifestations and Diagnostic Studies

    Hypertension is asymptomatic and also referred to as the "silent killer" until it progresses to a severe stage or causes target organ disease. Patients may experience symptoms stemming from the strain on blood vessels and tissues in various organs or the heart's increased workload.Physical exams might show no abnormalities other than high blood pressure. Signs of vascular damage, when present, correspond to the organs supplied by the affected vessels, leading to target organ damage. For...
    Obesity01:24

    Obesity

    The Body Mass Index (BMI) is a numerical value derived from a person's weight and height, used to categorize individuals into weight ranges. It is calculated using the formula: weight in kilograms divided by height in meters squared. Obesity is a health condition characterized by excessive accumulation of adipose tissue that poses health risks, often diagnosed with a BMI ≥ 30. This excess fat storage occurs when surplus dietary calories are converted into triglycerides and stored in adipocytes...
    Hypertension I: Introduction01:28

    Hypertension I: Introduction

    Hypertension is a widespread, long-term medical condition where blood pressure in the arteries remains elevated. It is characterized by systolic blood pressure readings of 130 mm Hg or above or diastolic blood pressure (DBP) readings of 80 mm Hg or higher. Unmanaged hypertension poses significant health risks, making the distinction between primary (or essential) hypertension and secondary hypertension crucial, as their management and implications vary.Primary HypertensionPrimary hypertension,...