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A novel antibacterial diterpene from Premna schimperi
S Habtemariam1, A I Gray, G W Halbert
1Department of Chemistry, Addis Ababa University, Ethiopia.
Planta Medica
|April 1, 1990
Abstract:
A novel diterpene, (5R, 8R, 9S, 10R)-12-oxo-ent-3,13(16)-clerodien-15-oic acid, has been obtained from the leaves of Premna schimperi (Verbenaceae) using an anti-microbial bioassay-guided isolation procedure. The diterpene was identified on the basis of spectroscopic data and is active against the Gram-positive bacteria Staphylococcus aureus and Bacillus subtilis in the concentration range 20-25 micrograms ml-1.